Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Expression of thrombospondin-2 (TSP-2), a matricellular protein with anti-angiogenic properties, is modulated in developing adipose tissue. To investigate a potential functional role of
TSP
-2 in adipose tissue angiogenesis and growth,
TSP
-2 deficient (TSP-2(-/-)) and wild-type littermate (TSP-2(+/+)) mice were kept on normal chow (standard fat diet (SFD)) or on high fat diet (HFD) for 15 weeks.
TSP
-2(-/-) mice kept on HFD had a significantly lower total body weight throughout the experimental period. Subcutaneous (SC) and gonadal (GON) fat mass were, however, not different, and their composition in terms of size and density of adipocytes and blood vessels was also comparable in both genotypes. Macrophage infiltration in SC or GON adipose tissues was not affected by
TSP
-2 deficiency.
TSP
-2 deficiency had no effect on adipose tissue mRNA expression of gelatinase A (MMP-2), whereas
gelatinase B
(MMP-9) was downregulated in SC and GON adipose tissues of
TSP
-2(-/-) mice on HFD. Glucose tolerance and insulin resistance tests were comparable for
TSP
-2(+/+) and
TSP
-2(-/-) mice.
TSP
-2 deficiency was not compensated by increased expression of TSP-1 in the
TSP
-2(-/-) mice. These data suggest that
TSP
-2, despite its reported anti-angiogenic properties, does not play an important functional role in adipose tissue related angiogenesis or associated fat development in mice.
...
PMID:Role of thrombospondin-2 in murine adipose tissue angiogenesis and development. 2181 50
In the present study the aim was to measure the levels of
Thrombospondin-1
(
TSP1
) and Lipocalin-2/
matrix metalloproteinase 9
(
MMP9
/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situation of a good control of the bacterial plaque, emphasizing the role of
TSP1
and
MMP9
/NGAL complex. GCF samples were collected from 16 young orthodontic patients requiring upper canine distalization (test tooth) with first premolar extraction. The contralateral canine (control tooth) was free from orthodontic force. For the orthodontic appliance, brackets Roth 0.018 inch with 0.012 inch NiTi archwire and a laceback were used.
TSP1
,
MMP9
/NGAL, and
MMP9
increased from 1 hour before activation of orthodontic appliance to a maximum at 8 hours for
MMP9
and 72 hours for
MMP9
/NGAL and
TSP1
. The results show a change in time of
TSP1
,
MMP9
/NGAL, and
MMP9
levels in GCF of patients with this method of orthodontic treatment. The powerful correlation of
MMP9
/NGAL with
TSP1
suggests their stronger involvement in angiogenesis processes in PDL during orthodontic periodontal remodeling, in the situation of a healthy periodontium and a good control of the bacterial plaque.
...
PMID:Involvement of TSP1 and MMP9/NGAL in angiogenesis during orthodontic periodontal remodeling. 2496 33
