Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis (CRS) that is characterized by intractable nasal polyp formation.
Eosinophil-derived neurotoxin
(
EDN
) is an eosinophil granule protein that is closely related to allergic inflammation, but the pathological implications of
EDN
in ECRS remain unknown. In this study, we evaluated the function of
EDN
in ECRS pathogenesis and assessed its potential as a disease activity marker. Serum
EDN
levels were significantly higher in patients with ECRS than in those with other nasal and paranasal diseases, and were positively correlated with clinical disease activity. Production of
EDN
from isolated human eosinophils was induced by stimulation with IL-5 in vitro. Human nasal epithelial cells were stimulated with
EDN
, and the resultant changes in gene expression were detected by RNA sequencing. Pathway analysis revealed that the major canonical pathway affected by
EDN
stimulation was 'regulation of the epithelial-mesenchymal transition pathway'; the only gene in this pathway to be up-regulated was
matrix metalloproteinase 9
(
MMP-9
). Consistent with this, immunostaining analysis revealed intense staining of both
EDN
and
MMP-9
in nasal polyps from patients with ECRS. In conclusion, our data demonstrate that serum
EDN
level is a useful marker for the evaluation of ECRS severity. Furthermore,
EDN
induces production of
MMP-9
from the nasal epithelium, which may be involved in the pathogenesis of ECRS.
...
PMID:Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity. 3023 72
