Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The majority of suggested mechanisms of
Borrelia
spreading inside
erythema
migrans (EM) are developed from
in vitro
studies and animal models. This report is the first to describe pathomorphological substrate of EM caused by
Borrelia spielmanii
in humans, addressing the hypothesis of enhanced
Borrelia
penetration through extracellular matrix. In the process of ruling out of atypical Masters' disease, we conducted a punch biopsy of suspected EM and a two-tier serology testing for Lyme borreliosis, where we registered antibodies against
B. spielmanii
. Skin biopsy showed CD4
+
and CD8
+
lymphocyte involvement and high activity of
matrix metalloproteinase 9
. No alterations were detected in distribution and morphology of collagen type I and IV. Therefore, it is suggested that other mechanisms should be considered as major contributing factors to local spreading of
B.
spielmanii
.
...
PMID:Mysterious path of
Borrelia spielmanii
: spreading without morphological alteration of collagen type I and IV. 3190 66
