Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-
PGP
(
N
-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma. In mice exposed to cigarette smoke or lipopolysaccharide, lung neutrophilic inflammation produces increased levels of MMP-9 (
matrix metalloproteinase 9
) that contributes to collagen breakdown and allows the release of ac-
PGP
tripeptides. By silencing CXCR2 gene expression in tumor cells, we show that these generated ac-
PGP
tripeptides exert a chemotactic activity on tumor cells in vivo by binding CXCR2.
...
PMID:Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis. 2930 14
