Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mammalian aminoacyl tRNA synthetases form a macromolecular protein complex with three non-enzymatic cofactors. Among these factors,
p43
is also secreted to work as a cytokine on endothelial as well as immune cells. Here we investigated the activity of
p43
in angiogenesis and determined the related mediators. It promoted the migration of endothelial cells at low dose but induced their apoptosis at high dose.
p43
at low concentration activated extracellular signal-regulating kinase, which resulted in the induction and activation of
matrix metalloproteinase 9
. In contrast,
p43
at high concentration activated Jun N-terminal kinase, which mediated apoptosis of endothelial cells. These results suggest that
p43
is a novel cytokine playing a dose-dependent biphasic role in angiogenesis.
...
PMID:Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. 1223 13
