Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recent evidence points to the protein arginine methyltransferase (PRMT) family of enzymes playing critical roles in cancer.
PRMT7
has been identified in several gene expression studies to be associated with increased metastasis and decreased survival in breast cancer patients. However, this has not been extensively studied. Here we report that
PRMT7
expression is significantly upregulated in both primary breast tumour tissues and in breast cancer lymph node metastases. We have demonstrated that reducing
PRMT7
levels in invasive breast cancer cells using RNA interference significantly decreased cell invasion in vitro and metastasis in vivo. Conversely, overexpression of
PRMT7
in non-aggressive MCF7 cells enhanced their invasiveness. Furthermore, we show that
PRMT7
induces the expression of matrix metalloproteinase 9 (MMP9), a well-known mediator of breast cancer metastasis. Importantly, we significantly rescued invasion of aggressive breast cancer cells depleted of
PRMT7
by the exogenous expression of
MMP9
. Our results demonstrate that upregulation of
PRMT7
in breast cancer may have a significant role in promoting cell invasion through the regulation of
MMP9
. This identifies
PRMT7
as a novel and potentially significant biomarker and therapeutic target for breast cancer.
...
PMID:Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression. 2560 49
