Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.3 (collagenase)
18,340 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagenase 13438
collagen 4986
MMP-1 3359
matrix metalloproteinase 1731
MMP-9 1380
MMP-2 1293
Sep 1232
MMP-3 1030
Mol 924
insulin 874
EPA 851
MMP-8 737
type I collagen 721
metalloproteinase 705
MMP-13 622
stromelysin 562
cytokine 550
fibronectin 533
TIMP-2 496
IL-6 464
hyaluronidase 446
tumor necrosis factor 399
TNF 396
MMP 372
tissue inhibitor of metalloproteinases 364
matrix metalloproteinase 2 332
AP-1 324
proteoglycan 303
SDS 301
p38 287
alkaline phosphatase 273
elastin 272
IL-1 269
MT1-MMP 265
albumin 247
IL-8 240
type II collagen 239
lipopolysaccharide 233
polypeptide 207
c-Jun 200
more...
Disease
tumor 1187
cancer 1141
osteoarthritis 519
rheumatoid arthritis 424
diabetes 380
arthritis 355
SDS 301
carcinoma 241
periodontitis 220
atherosclerosis 213
plaque 210
stroke 207
melanoma 202
metastases 196
breast cancer 187
liver fibrosis 145
cold 130
tumor growth 127
ischemia 123
tumor progression 123
cornea 112
carcinogenesis 109
hepatocellular carcinoma 108
SEM 107
cirrhosis 102
hypertension 102
periodontal disease 101
adenocarcinoma 98
brain edema 95
uterus 92
GSH 88
squamous cell carcinoma 86
Dupuytren 76
obesity 76
hyperglycemia 75
fibrosarcoma 74
MCF 74
prostate cancer 70
asthma 70
myocardial infarction 68
more...
Symptom
pain 127
skin damage 47
functional recovery 46
anesthesia 39
erythema 34
tremor 30
agitation 27
thinning 25
collapse 22
starvation 19
hyperoxia 16
fatigue 16
weakness 14
back pain 14
respiratory distress 14
hypothermia 13
flushing 13
diarrhea 10
low back pain 10
arthralgia 10
seizures 9
angina 8
stigma 6
cachexia 5
autodigestion 5
analgesia 5
abdominal pain 5
skin irritation 5
discomfort 4
polyuria 4
discomfort 4
HSA 4
cough 4
overweight 3
knee pain 3
dyspnea 3
ataxia 3
regurgitation 3
disturbed balance 3
Stiffness 3
more...
Drug
Dermatol 368
lysine 156
Gelatin 79
ABC 79
Gel 77
PTH 68
MAP 65
CaCl2 59
ascorbate 59
CaCl2 58
CaCl2 58
ROS 57
IFN-gamma 57
uPA 51
IL-2 49
CSF 43
Pronase 43
Indomethacin 41
balanced salt solution 38
Cardiovasc 37
vitamin E 32
Nephron 30
Angiotensin II 28
Asn 28
CTX 23
caffeine 22
ETS 22
Hyaluronidase 21
Ethanol 21
MRC 21
Hyaluronidase 21
CTX 20
Glucagon 20
CTX 20
Histamine 20
EE2 18
NADH 18
DNase I 18
ROC 17
Aprotinin 17
more...
Enzyme
collagenase 18340
MMP-3 1389
trypsin 1166
elastase 588
mitogen-activated protein kinase 571
hyaluronidase 506
interstitial collagenase 462
MMP 452
hyaluronidase 446
matrix metalloproteinase 2 316
alkaline phosphatase 275
pepsin 249
ERK 241
matrix metalloproteinase 9 232
urokinase-type plasminogen activator 226
plasmin 214
peroxidase 201
chymotrypsin 178
protein kinase C 177
DNase 177
protein kinase 166
neutrophil collagenase 129
lactate dehydrogenase 116
papain 111
adenylate cyclase 108
thrombin 106
cathepsin G 102
catalase 97
superoxide dismutase 95
focal adhesion kinase 93
neutrophil elastase 90
MEK 89
caspase-3 88
chondroitinase 87
chondroitinase 86
luciferase 86
ATPase 85
cathepsin B 84
reverse transcriptase 84
acetylcholinesterase 74
more...
Compound
Dec 1326
DNA 940
calcium 927
glucose 751
Clin 738
Collagenase 607
sodium 595
acetate 531
water 496
oxygen 486
Collagen 461
proline 453
sulfate 423
TNF 396
EDTA 373
EDTA 373
leucine 330
zinc 329
SDS 325
arginine 300
cAMP 277
Gly 268
serine 262
phosphate 259
cysteine 231
alanine 224
lysine 209
AMP 202
salt 183
PGE2 177
ATP 175
ethanol 173
urea 166
hyaluronic acid 165
nitric oxide 158
methionine 158
galactose 156
tyrosine 153
Insulin 145
potassium 139
more...