Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
collagenase
13438
collagen
4986
MMP-1
3359
matrix metalloproteinase
1731
MMP-9
1380
MMP-2
1293
Sep
1232
MMP-3
1030
Mol
924
insulin
874
EPA
851
MMP-8
737
type I collagen
721
metalloproteinase
705
MMP-13
622
stromelysin
562
cytokine
550
fibronectin
533
TIMP-2
496
IL-6
464
hyaluronidase
446
tumor necrosis factor
399
TNF
396
MMP
372
tissue inhibitor of metalloproteinases
364
matrix metalloproteinase 2
332
AP-1
324
proteoglycan
303
SDS
301
p38
287
alkaline phosphatase
273
elastin
272
IL-1
269
MT1-MMP
265
albumin
247
IL-8
240
type II collagen
239
lipopolysaccharide
233
polypeptide
207
c-Jun
200
more...
Disease
tumor
1187
cancer
1141
osteoarthritis
519
rheumatoid arthritis
424
diabetes
380
arthritis
355
SDS
301
carcinoma
241
periodontitis
220
atherosclerosis
213
plaque
210
stroke
207
melanoma
202
metastases
196
breast cancer
187
liver fibrosis
145
cold
130
tumor growth
127
ischemia
123
tumor progression
123
cornea
112
carcinogenesis
109
hepatocellular carcinoma
108
SEM
107
cirrhosis
102
hypertension
102
periodontal disease
101
adenocarcinoma
98
brain edema
95
uterus
92
GSH
88
squamous cell carcinoma
86
Dupuytren
76
obesity
76
hyperglycemia
75
fibrosarcoma
74
MCF
74
prostate cancer
70
asthma
70
myocardial infarction
68
more...
Symptom
pain
127
skin damage
47
functional recovery
46
anesthesia
39
erythema
34
tremor
30
agitation
27
thinning
25
collapse
22
starvation
19
hyperoxia
16
fatigue
16
weakness
14
back pain
14
respiratory distress
14
hypothermia
13
flushing
13
diarrhea
10
low back pain
10
arthralgia
10
seizures
9
angina
8
stigma
6
cachexia
5
autodigestion
5
analgesia
5
abdominal pain
5
skin irritation
5
discomfort
4
polyuria
4
discomfort
4
HSA
4
cough
4
overweight
3
knee pain
3
dyspnea
3
ataxia
3
regurgitation
3
disturbed balance
3
Stiffness
3
more...
Drug
Dermatol
368
lysine
156
Gelatin
79
ABC
79
Gel
77
PTH
68
MAP
65
CaCl2
59
ascorbate
59
CaCl2
58
CaCl2
58
ROS
57
IFN-gamma
57
uPA
51
IL-2
49
CSF
43
Pronase
43
Indomethacin
41
balanced salt solution
38
Cardiovasc
37
vitamin E
32
Nephron
30
Angiotensin II
28
Asn
28
CTX
23
caffeine
22
ETS
22
Hyaluronidase
21
Ethanol
21
MRC
21
Hyaluronidase
21
CTX
20
Glucagon
20
CTX
20
Histamine
20
EE2
18
NADH
18
DNase I
18
ROC
17
Aprotinin
17
more...
Enzyme
collagenase
18340
MMP-3
1389
trypsin
1166
elastase
588
mitogen-activated protein kinase
571
hyaluronidase
506
interstitial collagenase
462
MMP
452
hyaluronidase
446
matrix metalloproteinase 2
316
alkaline phosphatase
275
pepsin
249
ERK
241
matrix metalloproteinase 9
232
urokinase-type plasminogen activator
226
plasmin
214
peroxidase
201
chymotrypsin
178
protein kinase C
177
DNase
177
protein kinase
166
neutrophil collagenase
129
lactate dehydrogenase
116
papain
111
adenylate cyclase
108
thrombin
106
cathepsin G
102
catalase
97
superoxide dismutase
95
focal adhesion kinase
93
neutrophil elastase
90
MEK
89
caspase-3
88
chondroitinase
87
chondroitinase
86
luciferase
86
ATPase
85
cathepsin B
84
reverse transcriptase
84
acetylcholinesterase
74
more...
Compound
Dec
1326
DNA
940
calcium
927
glucose
751
Clin
738
Collagenase
607
sodium
595
acetate
531
water
496
oxygen
486
Collagen
461
proline
453
sulfate
423
TNF
396
EDTA
373
EDTA
373
leucine
330
zinc
329
SDS
325
arginine
300
cAMP
277
Gly
268
serine
262
phosphate
259
cysteine
231
alanine
224
lysine
209
AMP
202
salt
183
PGE2
177
ATP
175
ethanol
173
urea
166
hyaluronic acid
165
nitric oxide
158
methionine
158
galactose
156
tyrosine
153
Insulin
145
potassium
139
more...