Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.3 (collagenase)
 18,340 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagenase 13438
collagen 4986
MMP-1 3359
matrix metalloproteinase 1731
MMP-9 1380
MMP-2 1293
Sep 1232
MMP-3 1030
Mol 924
insulin 874
EPA 851
MMP-8 737
type I collagen 721
metalloproteinase 705
MMP-13 622
stromelysin 562
cytokine 550
fibronectin 533
TIMP-2 496
IL-6 464
hyaluronidase 446
tumor necrosis factor 399
TNF 396
MMP 372
tissue inhibitor of metalloproteinases 364
matrix metalloproteinase 2 332
AP-1 324
proteoglycan 303
SDS 301
p38 287
alkaline phosphatase 273
elastin 272
IL-1 269
MT1-MMP 265
albumin 247
IL-8 240
type II collagen 239
lipopolysaccharide 233
polypeptide 207
vascular endothelial growth factor 200
c-Jun 200
PLA 193
MMP-7 193
epidermal growth factor 190
TIMP 186
AMP 186
glycoprotein 183
urokinase-type plasminogen activator 178
ATP 175
MMP9 168
TNF-alpha 168
aggrecan 167
MAPK 164
glucagon 158
ERK 151
TGF-beta 145
interleukin-6 143
chymotrypsin 143
ERK1 139
serum albumin 135
JNK 133
casein 130
angiotensin II 116
caspase-3 115
metalloprotease 115
parathyroid hormone 115
COX-2 114
inducible nitric oxide synthase 112
transforming growth factor-beta 112
TIMP-3 110
plasminogen 110
plasminogen activator inhibitor-1 109
DNase 109
MMP-10 109
thrombin 109
MMP-12 108
smooth muscle actin 108
IL-1 beta 108
IL-10 107
c-fos 106
lactate dehydrogenase 106
type I procollagen 106
myeloperoxidase 104
adenylate cyclase 102
cyclooxygenase-2 98
VEGF 97
platelet-derived growth factor 96
lectin 96
CD44 93
p53 93
LPS 93
vimentin 93
osteogenic 92
extracellular signal-regulated kinase 92
SMA 91
ACTH 91
collagenase-3 90
mitogen-activated protein 90
interferon 89
GSH 88
matrilysin 87
chondroitinase 86
somatostatin 85
peroxidase 85
NMR 84
peptidase 84
cathepsin B 84
p65 84
endoplasmic reticulum 81
mast cell 81
serine protease 81
tumor necrosis factor alpha 81
ATPase 80
ABC 79
amylase 79
CD45 78
trypsin inhibitor 77
RPMI 77
superoxide dismutase 77
Trypsin 75
CO2 75
IFN 74
E-cadherin 74
matrix metalloprotease 73
membrane-bound 73
IL-4 73
lymphoid 73
Bcl-2 72
cathepsin G 72
osteocalcin 72
MMP1 72
transferrin 71
CD31 71
catalase 70
CD34 70
Cytokine 70
hemoglobin 70
acetylcholinesterase 69
calcitonin 68
IL-1 alpha 68
MCP-1 68
prolactin 68
ECM 67
decorin 66
neutrophil elastase 65
PTH 65
fibrinogen 65
osteopontin 63
alpha-smooth muscle actin 62
thrombospondin 61
acid phosphatase 61
lysozyme 61
EGF 61
esterase 61
fused 60
chemokine 60
hemopexin 60
CD4 60
neuraminidase 59
cyclooxygenase 59
more...
Disease
tumor 1187
cancer 1141
osteoarthritis 519
rheumatoid arthritis 424
diabetes 380
arthritis 355
SDS 301
carcinoma 241
periodontitis 220
atherosclerosis 213
plaque 210
stroke 207
melanoma 202
metastases 196
breast cancer 187
liver fibrosis 145
cold 130
tumor growth 127
tumor progression 123
ischemia 123
cornea 112
carcinogenesis 109
hepatocellular carcinoma 108
SEM 107
cirrhosis 102
hypertension 102
periodontal disease 101
adenocarcinoma 98
brain edema 95
uterus 92
GSH 88
squamous cell carcinoma 86
obesity 76
Dupuytren 76
hyperglycemia 75
fibrosarcoma 74
MCF 74
asthma 70
prostate cancer 70
myocardial infarction 68
osteoporosis 65
pulmonary fibrosis 63
osteosarcoma 61
lung cancer 61
epidermolysis bullosa 60
cholera 59
emphysema 58
heart failure 57
colorectal cancer 55
arthropathy 54
glomerulonephritis 53
tumorigenesis 53
EDC 52
tuberculosis 52
PSS 49
sarcoma 49
chondrosarcoma 48
sepsis 48
colon cancer 47
chronic obstructive pulmonary disease 47
Goodpasture's syndrome 46
cardiovascular disease 46
sepsis 46
Peyronie's disease 45
synovitis 45
nephritis 40
leukemia 40
gastric cancer 40
Dupuytren's disease 40
HIV 39
pertussis 38
worms 38
liver disease 38
primary tumor 37
glomerulosclerosis 37
glioma 36
lung carcinoma 36
lung disease 36
Alzheimer's disease 36
renal disease 36
infectious diseases 35
type 1 diabetes 35
skin cancer 35
Mycobacterium 35
multiple sclerosis 34
multiple myeloma 34
scleroderma 34
glioblastoma multiforme 33
depression 33
coronary artery disease 33
inflammatory bowel disease 33
idiopathic pulmonary fibrosis 33
periosteum 32
Brown 32
Dermal 32
volvulus 32
Evans 31
aggressiveness 31
chronic pancreatitis 30
gingivitis 30
Pancreas 30
Pancreas 30
disc degeneration 30
tendinitis 29
type 2 diabetes 29
Blocking 29
Crohn's disease 28
lymphoma 27
HGF 27
cerebral ischemia 26
pancreatic cancer 26
Adhesion 26
ATM 26
ovarian cancer 26
MIP 25
mammary tumor 25
adenoma 25
premature aging 25
acute myocardial infarction 24
virus infection 24
diabetic nephropathy 23
glioblastoma 23
proteinuria 23
preeclampsia 23
autoimmune disease 23
uterine cervix 22
oral cancer 22
Dissociation 22
systemic lupus erythematosus 22
abdominal aortic aneurysm 21
SAR 21
dental caries 21
neuroblastoma 21
cardiomyopathy 21
leg ulcers 20
pancreatitis 20
FBS 20
CTX 20
COL2A1 19
psoriasis 19
non-small cell lung cancer 19
ulcerative colitis 19
TEM 19
cystic fibrosis 19
hyperinsulinemia 18
TEM 18
fatty liver 18
PHA 18
renal cell carcinoma 18
bacterial infection 18
dysplasia 18
tumor angiogenesis 18
Plaque 17
mole 17
dilated cardiomyopathy 17
bladder cancer 17
skin disease 17
osteogenesis imperfecta 16
ventricular hypertrophy 16
blindness 16
more...
Symptom
pain 127
skin damage 47
functional recovery 46
anesthesia 39
erythema 34
tremor 30
agitation 27
thinning 25
collapse 22
starvation 19
hyperoxia 16
fatigue 16
back pain 14
respiratory distress 14
weakness 14
flushing 13
hypothermia 13
diarrhea 10
arthralgia 10
low back pain 10
seizures 9
angina 8
stigma 6
analgesia 5
skin irritation 5
autodigestion 5
cachexia 5
abdominal pain 5
cough 4
discomfort 4
polyuria 4
HSA 4
discomfort 4
Stiffness 3
dyspnea 3
knee pain 3
disturbed balance 3
ataxia 3
overweight 3
swollen joints 3
regurgitation 3
dry eye 3
photophobia 2
splenomegaly 2
bitter taste 2
Fluctuation 2
Central post-stroke pain 2
inanition 2
sciatica 2
acidity 2
Hudson 2
headache 2
shoulder pain 2
hepatomegaly 2
myalgia 2
distraction 2
dry skin 2
POA 2
Tenderness 2
Scratch 2
cerebellar ataxia 2
muscle stiffness 2
spasticity 2
rigors 2
spasm 2
stomach pain 1
tense 1
Procedural pain 1
musculoskeletal disability 1
Joint hypermobility 1
Decreased activity 1
neurological disability 1
DNA marker 1
acute stress 1
anorexia 1
Ill 1
loss of balance 1
Trembling 1
rundown 1
Anoxia 1
Stepping 1
fasciculation 1
Goodell's sign 1
Muscle soreness 1
Spots 1
Hegar's sign 1
Mills 1
tachypnea 1
Wind 1
nausea and vomiting 1
Quadriceps weakness 1
nerve pain 1
hemiplegia 1
cancer pain 1
hypercapnia 1
exhaustion 1
incoordination 1
vomiting 1
leg pain 1
chronic back pain 1
chills 1
muscle cramps 1
ENT 1
scaly skin 1
neck pain 1
polydipsia 1
eds 1
pedal edema 1
pelvic pain 1
chest pain 1
Drug
Dermatol 368
lysine 156
Gelatin 79
ABC 79
Gel 77
PTH 68
MAP 65
CaCl2 59
ascorbate 59
CaCl2 58
CaCl2 58
ROS 57
IFN-gamma 57
uPA 51
IL-2 49
CSF 43
Pronase 43
Indomethacin 41
balanced salt solution 38
Cardiovasc 37
vitamin E 32
Nephron 30
Asn 28
Angiotensin II 28
CTX 23
caffeine 22
ETS 22
Hyaluronidase 21
Ethanol 21
Hyaluronidase 21
MRC 21
CTX 20
Glucagon 20
Histamine 20
CTX 20
EE2 18
DNase I 18
NADH 18
Aprotinin 17
Nephron 17
lactose 17
Albumin 17
ROC 17
Forskolin 17
Doxycycline 16
Leaf 16
Ringer's solution 16
Mutagen 15
Monit 15
Retinoic acid 15
CDP 14
Hypaque 14
Hypaque 14
Fraction 14
Batimastat 13
Batimastat 13
Glutathione 12
citric acid 11
Dial 10
IL-11 10
Growth hormone 10
Growth hormone 10
IL-1ra 10
Asthma 10
Glycerol 9
Atropine 9
Metrizamide 9
Vitamin A 9
Fluorescein 9
Vitamin E 9
CCL 9
Heme 9
Phenytoin 8
NAG 8
ICI 8
Paraffin 8
Papain 8
Fructose 8
Ginseng 7
CAM 7
L-tyrosine 7
ETA 7
AMC 7
G418 7
ENT 7
Aloe 7
Nitric Oxide 6
Amiloride 6
Theophylline 6
KGF 6
Cilostazol 6
Amiloride 6
Prinomastat 6
Adriamycin 6
Monensin 6
G-CSF 5
Biopolymers 5
Emodin 5
Luteinizing 5
Guanidine 5
EPA 5
Estrogens 5
Tannic acid 5
Fluorescein 5
Emodin 5
PTC 5
Guanidine 5
ADR 5
ampicillin 5
Ouabain 5
Clonidine 5
NaI 4
Misoprostol 4
HCG 4
Silica 4
NaI 4
NH3 4
CLS 4
Secretin 4
TAT 4
p75 4
ZnCl2 4
PDL 4
nitroglycerin 4
Tacrolimus 4
Isoniazid 4
NaI 4
Marimastat 4
Lovastatin 4
ZnCl2 4
IFN-beta 4
NaI 4
Aminoguanidine 4
Portal 4
FLP 4
NBT 4
Simvastatin 3
Imiquimod 3
PCB 3
Norplant 3
Gold sodium thiomalate 3
Rosiglitazone 3
Gelfoam 3
Urokinase 3
DHT 3
Alanine 3
Cimetidine 3
Cimetidine 3
Methylprednisolone 3
SiO2 3
ALA 3
TAC 3
Norplant 3
Infliximab 3
Trocade 3
Taxol 3
EPI 3
BLM 3
Conray 3
Infliximab 3
more...
Enzyme
collagenase 18340
MMP-3 1389
trypsin 1166
elastase 588
mitogen-activated protein kinase 571
hyaluronidase 506
interstitial collagenase 462
MMP 452
hyaluronidase 446
matrix metalloproteinase 2 316
alkaline phosphatase 275
pepsin 249
ERK 241
matrix metalloproteinase 9 232
urokinase-type plasminogen activator 226
plasmin 214
peroxidase 201
chymotrypsin 178
DNase 177
protein kinase C 177
protein kinase 166
neutrophil collagenase 129
lactate dehydrogenase 116
papain 111
adenylate cyclase 108
thrombin 106
cathepsin G 102
catalase 97
superoxide dismutase 95
focal adhesion kinase 93
neutrophil elastase 90
MEK 89
caspase-3 88
chondroitinase 87
luciferase 86
chondroitinase 86
ATPase 85
cathepsin B 84
reverse transcriptase 84
acetylcholinesterase 74
tissue plasminogen activator 69
thermolysin 68
alanine aminotransferase 67
neuraminidase 66
aspartate aminotransferase 65
acid phosphatase 63
lysozyme 62
phospholipase C 61
cathepsin K 59
lipase 59
tyrosinase 56
phosphodiesterase 54
gamma-glutamyl transpeptidase 53
beta-glucuronidase 52
renin 50
prolyl hydroxylase 49
beta-galactosidase 49
cathepsin D 45
ACE 40
glutathione S-transferase 37
lysyl oxidase 36
RNase 36
kallikrein 36
RNase 35
chloramphenicol acetyltransferase 34
tryptase 33
phospholipase A2 32
phosphatidylinositol 3-kinase 32
CD10 32
RNA polymerase 32
TACE 32
glutathione peroxidase 31
glyceraldehyde-3-phosphate dehydrogenase 31
deoxyribonuclease 31
type III procollagen 30
deoxyribonuclease 30
xanthine oxidase 28
lipoprotein lipase 28
5'-nucleotidase 27
cathepsin L 26
MIP 25
proteinase K 25
subtilisin 25
transcriptase 25
ACS 24
collagenase 3 24
proteasome 24
glyceraldehyde-3-phosphate dehydrogenase 24
MAP 23
glyceraldehyde-3-phosphate dehydrogenase 22
NADPH oxidase 22
NADPH oxidase 22
AMPK 22
clostripain 21
transglutaminase 21
heparinase 20
macrophage elastase 20
chymopapain 20
NO synthase 20
cholinesterase 20
chymopapain 20
glutamine synthetase 19
heme oxygenase 19
tyrosine aminotransferase 19
ornithine decarboxylase 19
glutamate dehydrogenase 18
glutamate dehydrogenase 18
alcohol dehydrogenase 18
glutamate dehydrogenase 18
glyceraldehyde-3-phosphate dehydrogenase 18
creatine kinase 18
glyceraldehyde-3-phosphate dehydrogenase 18
glucose-6-phosphatase 17
pyruvate kinase 17
CD13 17
ribonuclease 17
ribonuclease 17
NOS 16
calcineurin 16
lipoxygenase 16
stromelysin-3 16
chymase 15
IKK 15
thromboplastin 15
AST 14
bromelain 14
leucine aminopeptidase 14
carbonic anhydrase 14
hexokinase 14
adenosine deaminase 14
adenosine deaminase 14
lysyl hydroxylase 13
succinate dehydrogenase 13
HSD 12
arginase 12
phosphoenolpyruvate carboxykinase 12
dipeptidyl peptidase IV 12
CPR 12
sulfatase 12
guanylate cyclase 12
3beta-hydroxysteroid dehydrogenase 12
glucose-6-phosphate dehydrogenase 12
glycerol-3-phosphate dehydrogenase 12
endonuclease 11
monoamine oxidase 11
phosphoenolpyruvate carboxykinase 11
phosphoenolpyruvate carboxykinase 11
furin 11
thymidine kinase 11
MEKK1 11
prolidase 10
DCF 10
phosphorylase 10
APC 10
caspase-8 10
glycerol-3-phosphate dehydrogenase 10
ficin 10
prolyl endopeptidase 10
aggrecanase-1 10
glucokinase 10
more...
Compound
Dec 1326
DNA 940
calcium 927
glucose 751
Clin 738
Collagenase 607
sodium 595
acetate 531
water 496
oxygen 486
Collagen 461
proline 453
sulfate 423
TNF 396
EDTA 373
EDTA 373
leucine 330
zinc 329
SDS 325
arginine 300
cAMP 277
Gly 268
serine 262
phosphate 259
cysteine 231
alanine 224
lysine 209
AMP 202
salt 183
PGE2 177
ATP 175
ethanol 173
urea 166
hyaluronic acid 165
nitric oxide 158
methionine 158
galactose 156
tyrosine 153
Insulin 145
potassium 139
hydrogen 135
PEG 134
NH2 134
retinoic acid 119
Phe 114
iron 112
MTT 111
bromide 110
PEG 98
nitrogen 96
HCl 96
CO2 95
GSH 94
GSH 94
ACTH 94
ammonium 93
aldosterone 93
DEAE 91
Cardiol 89
MDA 89
PGE 87
guanidine 85
glycerol 80
acetic acid 77
Trypsin 75
iodine 74
ASA 73
Asp 73
TCA 73
PMA 72
Ile 72
silver 71
PMA 68
threonine 66
His 64
aldehyde 63
CaCl2 59
H2O2 57
acrylamide 56
tryptophan 53
EDC 52
aldehyde 51
Mg2+ 51
MEK 51
tryptophan 50
Dexamethasone 49
prostaglandin E1 49
Triton X-100 49
tryptophan 49
tryptophan 49
glutamine 48
TPA 46
TPA 46
Progesterone 45
vitamin D 45
DMSO 44
Tris 43
copper 43
methanol 43
Optimal 41
CCl4 41
Heparin 41
Hydroxyproline 40
ADP 40
Cereb 38
creatinine 38
NAD 37
Indomethacin 37
Diabetol 36
THP 36
THP 35
cGMP 35
Tris 35
ADP 34
ADP 34
noradrenaline 34
glutamate 33
hexose 32
TACE 32
prostacyclin 32
Angiotensin II 31
2-mercaptoethanol 31
cobalt 31
ammonia 30
titanium 30
acetone 30
retinol 30
Adrenal 30
gallic acid 29
formaldehyde 29
Cortisol 29
CAT 28
NAD 28
CAT 28
ACh 28
N-acetylcysteine 28
CAT 28
manganese 27
chloroform 27
TSH 26
adenylate 26
selenium 26
cadmium 26
GTP 26
valine 26
NADPH 25
KOH 25
NADPH 25
MAP 25
fluorine 25
Estradiol 25
DPPH 25
Ascorbic acid 24
hexose 24
DNP 24
GlcNAc 24
hexose 24
5-HT 24
Phorbol 24
hexose 24
more...