Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We explored the clinical and pathological impact of
epidermal growth factor receptor
(
EGFR
) extracellular domain missense mutations. Retrospective assessment of 260 de novo glioblastoma patients revealed a significant reduction in overall survival of patients having tumors with
EGFR
mutations at alanine 289 (
EGFR
A289D/T/V
). Quantitative multi-parametric magnetic resonance imaging analyses indicated increased tumor invasion for
EGFR
A289D/T/V
mutants, corroborated in mice bearing intracranial tumors expressing
EGFR
A289V
and dependent on ERK-mediated expression of
matrix metalloproteinase-1
.
EGFR
A289V
tumor growth was attenuated with an antibody against a cryptic epitope, based on in silico simulation. The findings of this study indicate a highly invasive phenotype associated with the
EGFR
A289V
mutation in glioblastoma, postulating
EGFR
A289V
as a molecular marker for responsiveness to therapy with
EGFR
-targeting antibodies.
...
PMID:Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. 2999 Apr 98
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