Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Addition of
CoCl2
solutions to the culture media of confluent monolayers of lapine or human synoviocytes stimulated their production of the neutral proteinases
collagenase
, gelatinase, and caseinase. With lapine cells, maximum stimulation occurred at 10(-7) M
CoCl2
, while human cells required 10(-4)-10(-5) M
CoCl2
to achieve a maximum stimulation. Production of prostaglandin E2 by lapine cells was enhanced some 30-40% by concentrations of
CoCl2
that maximally stimulated synthesis of the neutral proteinases, whereas all concentrations of
CoCl2
slightly depressed the production of prostaglandin E2 by human cells. Lapine synovial cells that had been stimulated by
CoCl2
also produced a substance, or substances, that provoked the synthesis of
collagenase
, gelatinase, caseinase, and prostaglandin E2 by monolayers of articular chondrocytes. Chondrocytes themselves, however, resisted activation by
CoCl2
. These findings may be relevant to the aseptic loosening of joint prostheses.
...
PMID:The synovial production of collagenase and chondrocyte activating factors in response to cobalt. 283 55
