Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Monolayer cultures of rabbit chondrocytes were stimulated to produce
collagenase
with conditioned medium from human peripheral blood mononuclear cells (MCM), and the ability of
Razoxane
to modulate the production of
collagenase
and specific tissue inhibitor of metalloproteinases (TIMP) was studied. Collagenase production was inhibited and TIMP increased by
Razoxane
, in a dose-dependent manner, when cells were treated daily for 3 days. Over this period the effect of
Razoxane
was progressive; 50 micrograms/ml or less had no effect at day 1 but 50 micrograms/ml was effective by day 3. The effectiveness of
Razoxane
was inversely related to the degree of MCM stimulation and the confluency of the culture. On removal of the drug, chondrocytes stimulated with MCM recovered their ability to produce
collagenase
, and TIMP production returned to near normal. The results suggest that the ability of
Razoxane
to reduce
collagenase
and increase TIMP production may correlate with its effectiveness in treating psoriatic arthritis.
...
PMID:The effects of razoxane (ICRF 159) on the production of collagenase and inhibitor (TIMP) by stimulated rabbit articular chondrocytes. 631 74
