Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To investigate the invasive activity of thyroid cancer, an in situ hybridization study was carried out in 19 thyroid tumors, including nine papillary carcinomas, five follicular carcinomas and five follicular adenomas, by using a 35S-labeled
MMP-1
(
matrix metalloproteinase-1
) cDNA probe. The
MMP-1
gene was expressed not in the cancer cells but in the fibrous capsules of papillary carcinoma.
Thyroid cancer
is generally circumscribed by a fibrous capsule. We found that types I and III collagen constitute the fibrous capsule, and that the
MMP-1
gene was expressed in the outer border of these sites. These findings suggest that
MMP-1
plays an important role in the invasion of thyroid cancer.
...
PMID:Expression of MMP-1 in the capsule of thyroid cancer--relationship with invasiveness. 868 37
