Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recent human studies found that the mRNA expression level of
aryl-hydrocarbon receptor nuclear translocator 2
(
ARNT2
) was positively associated with the prognosis of breast cancer. In this study, we used small interfering RNA techniques to knockdown
ARNT2
expression in MCF7 human breast cancer cells, and found that an almost 40% downregulation of
ARNT2
mRNA expression increased the expression of sensitive to apoptosis gene (3.36-fold), and decreased the expression of von Hippel-Lindau (0.27-fold) and
matrix metalloproteinase-1
(0.35-fold). The metabolite analysis revealed the contents of glucose, glycine, betaine, phosphocholine, pyruvate and lactate involved in the hypoxia-inducible factor (HIF)-1-dependent glycolytic pathway were significantly lower in cells treated with siARNT2. Our results suggested that
ARNT2
might play an important role in the modulation of HIF-1-regulated signaling and metabolism.
...
PMID:siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells. 2194 17
