Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
ACTN4
is an actin-binding protein that participates in cytoskeleton organisation. It resides both in the cytoplasm and nucleus and physically associates with various transcription factors. Here, we describe an effect of
ACTN4
expression on transcriptional activity of the RelA/p65 subunit of NF-kB. We demonstrate that
ACTN4
enhances RelA/p65-dependant expression of c-fos, MMP-3 and
MMP-1
genes, but it does not affect TNC, ICAM1 and FN1 expression. Importantly, actin-binding domains of
ACTN4
are not critical for the nuclear translocation and co-activation of RelA/p65- dependent transcription. Collectively, our data suggest that in the nucleus,
ACTN4
functions as a selective transcriptional co-activator of RelA/p65.
...
PMID:Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. 3034 54
