Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of this study was to investigate the effect and mechanism of
Helicobacter pylori
infection in the invasion and metastasis of gastric cancer. Specimens from 80 patients with gastric cancer (of which 20 patients had
metastatic gastric cancer
) and 40 patients with chronic gastritis were included in this study.
H. pylori
infection was determined by ELISA and the expression of
matrix metalloproteinase-1
(
MMP-1
) and MMP-10 was observed using immunohistochemistry. The correlation between
H. pylori
infection and the clinical pathological features of gastric cancer was analyzed by SPSS 13.0 software. The protein expression levels of
MMP-1
and MMP-10 in MGC-803 cells infected with
H. pylori
were analyzed using western blotting.
H. pylori
infection was found in 62 of the 80 patients with gastric cancer and in 13 of the 40 patients with chronic gastritis. In addition,
H. pylori
infection was correlated with the staging and lymph node metastasis, but not with the gender, age and histological types of patients.
H. pylori
infection was also significantly correlated with the expression of
MMP-1
and MMP-10 (r=0.8718, P<0.05 and r=0.5477, P<0.05, respectively). The expression of
MMP-1
and MMP-10 was significantly upregulated following induction by
H. pylori
infection (P<0.05), with significant effects occurring following infection for 12 and 6 h, respectively.
H. pylori
infection may promote the invasion and metastasis of gastric cancer by increasing the expression of
MMP-1
and MMP-10.
...
PMID:
Helicobacter pylori
infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase-1 and matrix metalloproteinase-10. 2512 May 97
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with
metastatic gastric cancer
, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and
collagenase
activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
...
PMID:Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27. 2938 75
