Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
Tyzzer's disease
organism was grown in primary monolayer cultures of adult mouse hepatocytes prepared by
collagenase
perfusion. The organisms produced a plaque-like cytopathic effect involving almost the whole culture around 72 h post-infection when the bacterial growth reached a maximum. The organisms showed specific immunofluorescence, and electron microscopy revealed that intracellular organisms had peritrichous flagella and underwent cell division. After intravenous inoculation of the infected cell culture into mice, necrotic hepatitis was produced and the organisms, recovered from the liver lesion, could be propagated in primary culture of mouse hepatocytes.
...
PMID:Growth of Tyzzer's organism in primary monolayer cultures of adult mouse hepatocytes. 634 4
