Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteoarthritis is a common chronic and progressively degenerative joint condition. The stem bark of
Eucommia ulmoides
Oliver (a member of the Eucommiaceae family), which is also known as Du-Zhong, is a traditional Chinese medicine commonly used for the treatment of rheumatoid arthritis. However, the mechanisms underlying the effects of
Eucommia
in the treatment of
arthritis of the knee
require further study. The present study investigated the effects of an aqueous extract of
Eucommia
on the articular cartilage (by Mankin's grade) and the levels of
matrix metalloproteinase-1
(
MMP-1
), MMP-3 and MMP-13 in the serum and synovial fluid in a rat model of osteoarthritis. The serum levels of
MMP-1
, -3 and -13 were measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) at weeks 1, 2 and 4. The levels of
MMP-1
, -3 and 13 were significantly decreased in the rats treated with
Eucommia
compared with those in the control rats (P<0.05). Histopathological examination results indicated a lower Mankin's grade in the
Eucommia
group compared with that of the control rats. Therefore,
Eucommia
was demonstrated to have a cartilage-protecting effect in rats with osteoarthritis, potentially by improving cartilage metabolism, regulating the degradation of the extracellular matrix of the articular cartilage, and inhibiting apoptosis in chondrocytes, thereby slowing down joint degeneration.
...
PMID:Effects of an aqueous extract of
Eucommia
on articular cartilage in a rat model of osteoarthritis of the knee. 2413 47
