Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.3 (collagenase)
 18,340 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dupuytren's disease, first described in 1831 by G. Dupuytren, is a mysterious retractile fibrosis of the palmodigital aponeurosis. Its etiology remains unclear despite various risk factors identified including genetics factors. Most patients are middle age males and have Caucasian's origin (northern Europe). Among risk factors, diabetes is the most frequent associated disease. Characteristic clinical signs are the palmar nodules, ombilications and cords causing finger contractures. There is various clinical features with also ectopic signs: Ledderhose's disease, Lapeyronie's disease and dorsal pads. There is no conservative treatment. The treatment is justified when the patient can't put his hand flat on the table (Hueston's test). Therapeutic strategy depends on the extent and level of retractions. Needle fasciotomy is preferred for palmar forms. Surgery (fasciectomy) is the standard procedure for digitopalmar forms because of complexity of band's anatomy and its proximity with the neurovascular bundle. Enzymatic fasciotomy using collagenase injections have been recently developped. Published results are hopeful and assessment in Europe is underway. Anyhow the used technique, recurrence is frequent and can be treated by dermofasciectomy. Palliative surgery, as arthrodesis, can be necessary in case of recurrency.
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PMID:[Dupuytren's disease]. 2442 98

Plantar fibromatosis (Ledderhose disease) is a rare, benign, hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia. This condition can be locally aggressive, and often results in pain, functional disability, and decreased quality of life. Diagnosis is primarily clinical, but MRI and ultrasound are useful confirmatory adjuncts. Given the benign nature of this condition, treatment has historically involved symptomatic management. A multitude of conservative treatment strategies supported by varying levels of evidence have been described mostly in small-scale trials. These therapies include steroid injections, verapamil, radiation therapy, extracorporeal shock wave therapy, tamoxifen, and collagenase. When conservative measures fail, surgical removal of fibromas and adjacent plantar fascia is often done, although recurrence is common. This review aims to provide a broad overview of the clinical features of this disease as well as the current treatment strategies being employed in the management of this condition.
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PMID:The etiology, evaluation, and management of plantar fibromatosis. 3077 65

Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Traditionally, surgical intervention has been the most common treatment for plantar fibromatosis. However, numerous studies have reported high recurrence rates of plantar fibromatosis after surgical intervention, as well as wound healing difficulties and nerve injury. Plantar fibromatosis often coexists with other superficial fibrous diseases such as Dupuytren's contracture and Peyronie's disease; immunohistochemical and ultrastructural analyses suggest a relationship between Ledderhose's disease and Dupuytren's contracture. The US Food and Drug Administration approved collagenase Clostridium histolyticum for the treatment of Dupuytren's contracture in 2010 and Peyronie's disease in 2013. This case study presents the successful treatment of Ledderhose's disease almost 4 years (45.5 months) after off-label use of collagenase C. histolyticum injection in a 22-year-old white female who had recurrent plantar fibromatosis after surgical intervention.
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PMID:The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study. 3167 81