Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A guanine insertion polymorphism in
matrix metalloproteinase-1
promoter (
MMP-1
2G) is linked to early onset and aggressiveness in cancer. We determined the role of
MMP-1
2G on
MMP-1
expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However,
MMP-1
expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to
in situ breast cancer
.
MMP-1
2G insertion polymorphism in the invasive group also correlated significantly with the expression of
MMP-1
and breast cancer prognostic markers HER2 and P53.
...
PMID:Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. 2201 Dec 82
