Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of 4 proteolytic enzymes, alpha-chymotrypsin, bromeline,
collagenase
, and lysozyme on amyloid tissue sections from a patient with familial amyloidotic
polyneuropathy
(FAP) were evaluated. Degradation of amyloid fibrils was significant with alpha-chymotrypsin, moderate with bromeline and
collagenase
, and slight with lysozyme. All of these proteases except
collagenase
are used as oral mucolytics in humans. The possibility of their clinical usefulness in the treatment or prevention of the development of FAP is discussed.
...
PMID:In vitro degradation of amyloid material by four proteases in tissue of a patient with familial amyloidotic polyneuropathy. 283 42
