Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.3 (
collagenase
)
18,340
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neonates with premature rupture of the membrane and
oligohydramnios
have an increased risk of acute respiratory morbidity. The aims of this study are to investigate the effects of experimental
oligohydramnios
on transforming growth factor (TGF)-beta1 and connective tissue growth factor (CTGF) expressions and collagen level in fetal rat lungs. On day 16 of gestation, we anesthetized timed pregnant Sprague-Dawley dams, punctured the uterine wall and fetal membranes of each amniotic sac which resulted in
oligohydramnios
. Fetuses in the opposite uterine horn served as controls. On days 19 and 21 of gestation, fetuses were delivered by cesarean section. Rats exposed to
oligohydramnios
exhibited significantly lower lung weight/body weight ratios on days 19 and 21 of gestation than did the control rats. Lung type I collagen and TGF-beta1 mRNA expressions and lung collagen levels were significantly decreased in rats exposed to
oligohydramnios
on days 19 and 21 of gestation. Type I collagen and inhibitors of
metalloproteinase-1
(TIMP-1) proteins were decreased and
matrix metalloproteinase-1
(
MMP-1
) was increased in
oligohydramnios
-exposed rats on days 19 and 21 of gestation. CTGF mRNA expressions were comparable between control and
oligohydramnios
-exposed rats on days 19 and 21 of gestation. These data suggest that downregulation of collagen might be involved in the pathogenesis of
oligohydramnios
-induced respiratory morbidity.
...
PMID:Experimental oligohydramnios decreases collagen in hypoplastic fetal rat lungs. 1879 Nov 29
