Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.3 (collagenase)
 18,340 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Anti-aortic antibodies were frequently detected from the sera of patients with aortitis syndrome. 2. Aortic antigens were demonstrated to exist mainly in the media. The antigenicity was inactivated by collagenase, trypsin and pepsin, but not by DNase-I. Analyses of aortic antigens were also made by ultracentrifugation and column chromatography. 3. Experimental arteritis could be produced in animals by isologous active immunization and heterologous passive immunization. 4. From these results, participation of antigen-antibody reaction in the development of the disease has been speculated. Possible role of streptococcal infection as one of the trigger mechanisms in antibody production has been suggested in combination with evidence indicating hypersensitivity of the patients to infections.
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PMID:Immunological aspects of aortitis syndrome. 112 Oct 58

To clarify the immunological mechanisms in poststreptococcal acute glomeulonephritis (PSAGN) and anaphylactoid purpura (AP), anti-streptococcal cell membrane (anti-SCM) and anti-human glomerular basement membrane (anti-GBM) titers in the sera of patients with PSAGN and AP were determined by passive hemagglutination with chromic chloride-treated sheep erythrocytes. Sodium lauryl sulfate (SLS) soluble SCM and collagenase soluble GBM were used as soluble antigens. Positive anti-SCM titers (greater than 1:8) were demonstrated in 10 of 14 patients (71.4%) with PSAGN and in 4 of 9 patients (44.4%) with AP with evidence of antecedent streptococcal infection. Two of 4 patients with AP without evidence of antecedent streptococcal infection had positive anti-SCM titers. No correlation was noted between anti-streptolysin O (ASO) titers and anti-SCM titers in patients with PSAGN or AP, but many patients with high ASO titers also had high anti-SCM titers. No positive anti-GBM reactions were detected in patients with PSAGN or AP. No cross-reactions were noted between SLS soluble SCM and collagenase soluble GBM.
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PMID:Anti-streptococcal cell membrane and anti-human glomerular basement membrane titers in sera of patients with poststreptococcal acute glomerulonephritis and anaphylactoid purpura. 635 77