Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.24.27 (thermolysin)
 1,894 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Highly purified elastin from bovine ligamentum nuchae was submitted to partial alkaline hydrolysis (37 degree C, 72 H, 1 N KOH in 80 p. 100 aqueous ethanol). The non-coacervable fractions were submitted to isoelectrofocusing and five kappa-elastin fractions were obtained. The amino-acid compositions, the N-terminal amino-acids, the molecular weights and the thermolysin digests of each fraction were determined by various techniques. The average MW was about 14,500 (150 - 166 amino-acids). These results suggest that the distribution of cross-linking agents in fibrous elastin may not be uniform. The results also show that in certain cross-linked regions of similar molecular weight and size appearing to be composed of different polypeptides sequences containing different amounts of cross-links.
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PMID:Partial characterization of peptide fragment purified by isoelectrofocusing after organo alkaline hydrolysis of bovine ligamentum nuchae elastin. 732 23