Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.23 (MMP)
 4,246 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MMP 3744
matrix metalloproteinase 1052
MMP-2 796
MMP-9 697
collagen 625
matrilysin 449
metalloproteinase 448
Mol 326
Sep 281
EPA 275
MMP-1 268
matrix metalloproteinase 2 245
TIMP-2 233
MMP-3 222
MMP9 201
TIMP 190
MT1-MMP 186
MMP-7 181
collagenase 161
stromelysin 150
caspase-3 150
ROS 149
fibronectin 145
MMP-13 141
cytokine 139
MMP7 128
TNF 125
p38 122
Bcl-2 118
MAPK 110
GSH 108
MMP2 105
ERK 104
IL-6 93
type I collagen 92
urokinase-type plasminogen activator 87
ERK1 87
vascular endothelial growth factor 85
tumor necrosis factor 84
JNK 80
VEGF 73
tissue inhibitor of metalloproteinases 72
E-cadherin 69
PI3K 68
MMP-8 65
MMP14 65
ECM 63
p53 62
MMP1 59
ATP 59
matrix metalloprotease 59
hemopexin 59
proteoglycan 59
aggrecan 58
metalloprotease 56
IL-8 56
elastin 55
AP-1 54
TIMP-3 54
AKT 52
plasminogen 51
PARP 51
cytochrome c 49
caspase-9 49
fur 47
matrix metalloproteinase 9 46
catenin 45
TNF-alpha 45
MMP-12 44
collagenase-3 43
MMP3 42
membrane-bound 42
CD44 42
MEK 41
lipopolysaccharide 40
SOD 39
annexin V 39
EGFR 39
MT1 38
IL-1 38
COX-2 37
MMP13 36
TIMP1 36
tissue inhibitor of metalloproteinases-2 36
chemokine 36
SMA 35
inducible nitric oxide synthase 35
plasminogen activator inhibitor-1 35
c-Jun 34
Metalloproteinase 34
HT-1080 33
beta-catenin 33
epidermal growth factor receptor 32
insulin 32
NMR 31
focal adhesion kinase 31
tyrosine kinase 31
LDH 31
extracellular signal-regulated kinase 30
thrombin 30
TGF-beta 29
PLA 29
casein 29
stromelysin-3 28
LPS 28
FAK 28
osteopontin 28
matrix metalloproteinase 1 27
caspase-8 27
IL-10 27
NAC 27
tumor necrosis factor alpha 26
TIMP2 26
MMP-10 26
Fas 26
CD147 26
angiotensin II 26
SDS 26
endoplasmic reticulum 25
EGF 25
SM3 25
superoxide dismutase 25
STAT3 25
MT2-MMP 25
serine protease 25
thrombospondin 25
CXCR4 25
p65 24
smooth muscle actin 24
interferon 24
MMP-11 24
TIMP-4 24
THP 23
interleukin-6 23
fibrinogen 23
vimentin 23
epidermal growth factor 23
Ang II 22
osteosarcoma 22
RhoA 22
Rho 22
IFN 22
PEG 21
mitogen-activated protein 21
TACE 20
vascular endothelium 20
transforming growth factor-beta 20
PDGF 20
p21 20
proteasome inhibitor 19
PKC 19
urokinase plasminogen activator 19
membrane protein 19
catalase 19
FGF 19
colon carcinoma 18
hepatocyte growth factor 18
PBS 18
cyclin D1 18
N-cadherin 18
more...
Disease
cancer 913
tumor 772
carcinoma 190
breast cancer 156
tumor progression 134
tumor growth 128
metastases 124
GSH 108
osteoarthritis 101
carcinogenesis 81
arthritis 76
lung cancer 76
MCF 72
tumorigenesis 68
atherosclerosis 68
prostate cancer 66
adenocarcinoma 65
colorectal cancer 65
colon cancer 63
rheumatoid arthritis 61
hepatocellular carcinoma 61
squamous cell carcinoma 60
fibrosarcoma 58
melanoma 58
glioma 57
plaque 50
hypertension 49
diabetes 42
glioblastoma 40
ischemia 40
gastric cancer 39
stroke 38
aggressiveness 37
myocardial infarction 35
ovarian cancer 34
Alzheimer's disease 34
cervical cancer 31
leukemia 29
heart failure 28
pancreatic cancer 28
SDS 26
tumor angiogenesis 24
epithelial ovarian cancer 24
osteosarcoma 23
primary tumor 22
asthma 22
cardiovascular disease 22
obesity 22
liver fibrosis 22
uterus 22
periodontitis 21
multiple sclerosis 20
cerebral ischemia 19
pulmonary fibrosis 19
dysplasia 19
chronic obstructive pulmonary disease 18
Parkinson's disease 18
renal cell carcinoma 17
endometrial cancer 16
inflammatory bowel disease 16
Mycobacterium 16
lung carcinoma 16
glioblastoma multiforme 15
non-small cell lung cancer 14
emphysema 14
arthropathy 14
abdominal aortic aneurysm 14
adenoma 13
invasive cancer 13
brain tumor 13
Blocking 13
HGF 13
skin cancer 13
mammary tumor 13
neuroblastoma 13
lymphoma 13
TEM 13
cornea 12
TEM 12
cirrhosis 12
tuberculosis 12
bladder cancer 12
infectious diseases 12
renal disease 12
osteoporosis 11
idiopathic pulmonary fibrosis 11
cardiomyopathy 11
encephalomyelitis 11
ulcerative colitis 11
APC 11
SAR 10
acute myocardial infarction 10
liver cancer 10
CTX 10
HIV 10
systemic lupus erythematosus 10
cognitive impairment 10
multiple myeloma 10
blindness 10
acute myeloid leukemia 10
Crohn's disease 9
endometriosis 9
epithelial tumor 9
bone metastases 9
EMT 9
NOD 9
hyperglycemia 9
dilated cardiomyopathy 9
Melanoma 9
type 2 diabetes 9
cold 9
glomerulosclerosis 9
pemphigoid 9
type 1 diabetes 9
preeclampsia 9
chondrosarcoma 8
metastatic breast cancer 8
lung disease 8
AGS 8
myocardial ischemia 8
diabetic nephropathy 8
oral cancer 8
colitis 8
vascular disease 8
proteinuria 8
SCID 8
periodontal disease 7
glomerulonephritis 7
liver metastases 7
autoimmune disease 7
sepsis 7
infertility 7
AIDS 7
immunopathology 7
Dukes 7
renal cancer 7
pertussis 7
sarcoma 7
Osteosarcoma 7
aggression 7
sepsis 7
Osteosarcoma 7
acute lymphoblastic leukemia 7
COL2A1 7
disc degeneration 7
small cell lung cancer 7
SEM 7
congestive heart failure 7
brain cancer 7
encephalitis 7
lupus 6
influenza 6
Infection 6
ATM 6
liver disease 6
lung metastases 6
Dermal 6
mimicry 6
chronic pancreatitis 6
pneumonia 6
more...
Symptom
collapse 21
pain 17
skin damage 6
acidity 6
thinning 5
dry eye 5
cough 4
functional recovery 4
anesthesia 4
angina 4
starvation 4
erythema 3
exhaustion 3
low back pain 3
weakness 3
Scratch 2
pelvic pain 2
seizures 2
arthralgia 2
wheezing 1
ataxia 1
discomfort 1
spasticity 1
nausea 1
exertional dyspnea 1
constipation 1
hyperoxia 1
hypothermia 1
muscle cramps 1
HSA 1
diarrhea 1
chest pain 1
discomfort 1
acute stress 1
snoring 1
Sore 1
Trembling 1
distraction 1
splenomegaly 1
dizziness 1
back pain 1
memory loss 1
dyspnea 1
shortness of breath 1
overweight 1
Fluctuation 1
fatigue 1
Chest discomfort 1
upset stomach 1
Wind 1
flushing 1
knee pain 1
joint stiffness 1
headache 1
neurological disability 1
spasm 1
skin irritation 1
swollen joints 1
Drug
ROS 149
Gelatin 33
uPA 33
Dermatol 31
lysine 28
Cardiovasc 17
Asn 14
Batimastat 13
MAP 13
Batimastat 13
ascorbate 12
Monit 11
IFN-gamma 11
CTX 11
CTX 10
Gel 10
CTX 10
CSF 9
Marimastat 9
Doxycycline 8
Ilomastat 7
IL-2 6
Asthma 5
CAM 5
ADR 4
Arsenic trioxide 4
NADH 4
CaCl2 4
Glutathione 4
MRC 4
vitamin E 4
Angiotensin II 4
ROC 4
CaCl2 4
G-CSF 4
CaCl2 4
DM1 3
Taxol 3
Phosphatidylserine 3
EE2 3
Emodin 3
Heme 3
PTH 3
Indomethacin 3
lactose 3
IFN-beta 3
Aprotinin 3
Ethanol 3
Fluorescein 3
p75 3
Emodin 3
Nitric Oxide 3
ZnO 3
Simvastatin 2
Fluorescein 2
ABC 2
G418 2
Adriamycin 2
BLM 2
BTC 2
RFP 2
Propofol 2
ADM 2
Epigallocatechin 2
NBT 2
Histamine 2
Myricetin 2
Dakar 2
Leaf 2
TAK 2
Prinomastat 2
Auranofin 2
Infliximab 2
Rosiglitazone 2
Oseltamivir 2
Ouabain 2
Infliximab 2
Gefitinib 1
Parkin 1
Tolfenamic acid 1
Albumin 1
NOV 1
Hyaluronidase 1
AMC 1
Trocade 1
Growth hormone 1
Flavopiridol 1
CPT-11 1
CTT 1
Codeine 1
S-Adenosyl-L-Homocysteine 1
Clamoxyl 1
Condurango 1
Luteinizing 1
KGF 1
Growth hormone 1
ICI 1
Adalimumab 1
Itraconazole 1
Hyaluronidase 1
Herceptin 1
Glide 1
Activin 1
Meth 1
Glycyrrhiza 1
Casodex 1
NVP 1
VCR 1
Tranilast 1
Estrogens 1
Rebamipide 1
citric acid 1
Mercaptopurine 1
CER 1
Ginseng 1
Trilostane 1
Nephron 1
niacin 1
Aloe 1
Bayer 1
CLS 1
Theophylline 1
VCR 1
Zoledronic acid 1
ETS 1
Lercanidipine 1
Allergen 1
Cibacron Blue 1
IL-11 1
ZnCl2 1
NAG 1
Ginger 1
2-Methoxyestradiol 1
ROX 1
DPA 1
Parkin 1
Atropine 1
Mutagen 1
Glutamic acid 1
Moxifloxacin 1
Codeine 1
EPI 1
balanced salt solution 1
ALA 1
LCM 1
Bosutinib 1
ZnCl2 1
Alanine 1
Vitamin A 1
IPM 1
TAT 1
Raloxifene 1
R1881 1
Aclarubicin 1
Anakinra 1
PCP 1
LCM 1
TTC 1
Azithromycin 1
Zebularine 1
more...
Enzyme
MMP 4246
collagenase 452
MMP-3 302
mitogen-activated protein kinase 270
matrix metalloproteinase 2 188
ERK 174
matrix metalloproteinase 9 159
caspase-3 120
urokinase-type plasminogen activator 107
focal adhesion kinase 86
interstitial collagenase 75
superoxide dismutase 60
MEK 59
PARP 56
plasmin 53
furin 47
protein kinase C 43
protein kinase 38
catalase 36
caspase-9 36
trypsin 35
elastase 34
reverse transcriptase 34
tissue plasminogen activator 31
luciferase 31
thrombin 30
stromelysin-3 22
macrophage elastase 21
peroxidase 21
caspase-8 20
TACE 20
CD10 19
alanine aminotransferase 16
proteasome 15
alkaline phosphatase 15
phosphatidylinositol 3-kinase 14
neutrophil collagenase 14
lactate dehydrogenase 14
glutathione S-transferase 13
renin 13
aspartate aminotransferase 13
NADPH oxidase 13
GSK 12
NADPH oxidase 12
matrix metalloproteinase 14 12
APC 12
phosphoinositide 3-kinase 12
AMP-activated protein kinase 11
RNA polymerase 10
AST 10
cathepsin B 10
cathepsin K 10
ACS 10
neutrophil elastase 10
phospholipase C 9
thiopurine methyltransferase 9
glutathione peroxidase 8
MAP 8
phospholipase A2 8
MPP 8
proprotein convertase 8
creatine kinase 8
transcriptase 8
AMPK 7
collagenase 3 7
cdc2 7
lysozyme 7
NO synthase 7
ATPase 7
complex I 6
RNase 6
RNase 6
AMPK 6
glyceraldehyde-3-phosphate dehydrogenase 6
hyaluronidase 6
MIP 6
cathepsin G 6
glyceraldehyde-3-phosphate dehydrogenase 5
kallikrein 5
type III procollagen 5
NOS 5
matrilysin-2 5
chloramphenicol acetyltransferase 5
glyceraldehyde-3-phosphate dehydrogenase 5
calcineurin 5
arginase 5
aggrecanase-1 5
hyaluronidase 5
glyceraldehyde-3-phosphate dehydrogenase 4
xanthine oxidase 4
BAL 4
kinesin 4
DNA methyltransferase 4
glyceraldehyde-3-phosphate dehydrogenase 4
ACE 4
NQO1 4
tryptase 4
thromboplastin 4
hatching enzyme 4
matriptase 4
prostate-specific antigen 4
caspase-1 4
endothelin-converting enzyme 4
CD13 4
lysyl oxidase 4
DCF 3
CAD 3
cytochrome oxidase 3
phospholipase D 3
matriptase 3
MDR 3
thermolysin 3
IKK 3
CAD 3
CAD 3
gamma-glutamyl transpeptidase 3
glucose oxidase 3
cathepsin L 3
lipase 3
cathepsin S 3
chymase 3
heparinase 3
lipoxygenase 3
pepsin 3
chymotrypsin 3
neuraminidase 3
beta-galactosidase 3
STR 3
prolyl hydroxylase 3
topoisomerase 3
acid phosphatase 3
TSP-1 3
topoisomerase 3
sialidase 2
CEP 2
aldehyde dehydrogenase 2
CPS 2
tissue kallikrein 2
endoglycosidase H 2
astacin 2
aconitase 2
transglutaminase 2
cathepsin H 2
TdT 2
prostaglandin synthetase 2
MAT 2
myosin light chain kinase 2
heme oxygenase 2
HIV-1 protease 2
MAT 2
angiotensin-converting enzyme 2 2
proteinase K 2
FAST 2
carboxypeptidase A 2
carbonic anhydrase 2
CYP3A4 2
DNA polymerase 2
CEP 2
m-calpain 2
lysyl hydroxylase 2
more...
Compound
Dec 288
oxygen 258
DNA 203
Clin 137
zinc 136
TNF 125
GSH 110
GSH 110
calcium 96
cysteine 92
MDA 83
MTT 80
acetate 76
water 71
leucine 70
tyrosine 65
ASA 65
arginine 63
glucose 62
Gly 61
serine 59
ATP 59
alanine 56
Collagen 54
sulfate 46
nitric oxide 46
hydrogen 44
lysine 43
N-acetylcysteine 43
MEK 40
PEG 37
EDTA 36
EDTA 36
PEG 31
Asp 30
NH2 29
proline 28
phosphate 28
Panam 27
methionine 27
SDS 26
Phe 26
Collagenase 26
sodium 25
hyaluronic acid 24
THP 23
THP 23
ethanol 23
retinoic acid 22
salt 22
galactose 21
Cardiol 21
threonine 21
TACE 20
H2O2 20
Ang II 19
iodine 19
CAT 17
PGE2 17
MEP 17
MEP 17
His 17
CAT 17
CAT 17
PMA 16
cAMP 15
PMA 15
COS 15
BSO 14
TEM 14
urea 13
nitrogen 13
iron 13
DEHP 13
Cyt 13
copper 12
ADP 12
ADP 12
gallic acid 12
Ile 12
PGE 12
ADP 12
CTX 11
methanol 11
bromide 11
glutamate 11
TOF 10
ACS 10
ACS 10
TNM 10
BAL 10
vitamin D 10
2-ethylhexyl 9
2-ethylhexyl 9
2-ethylhexyl 9
silver 9
ADR 9
MAP 9
creatinine 9
GSSG 9
glutamine 9
Vimentin 9
ADP-ribose 8
MPP 8
nitrate 8
tryptophan 8
Thrombin 8
Insulin 8
MPP 8
phenol 8
tryptophan 8
phthalic acid 8
dUTP 8
DMSO 8
Curcumin 8
Doxycycline 8
GTP 8
AMP 7
TPA 7
DBP 7
potassium 7
manganese 7
Pac 7
DMP 7
Genistein 7
CAM 7
tryptophan 7
NAD 7
tryptophan 7
Propyl gallate 7
DBP 7
TPA 7
DDP 6
ethyl acetate 6
DMP 6
Pyrogallol 6
Elastin 6
pyrrolidine 6
cadmium 6
cobalt 6
MCP 6
cyanide 6
hexane 6
Triton X-100 6
DMP 6
Adriamycin 6
glutamic acid 6
DMP 6
pyrimidine 6
Angiotensin II 6
NAD 6
pyrimidine 6
H2S 5
acridine 5
Cysteine 5
Minocycline 5
pyrrolidine 5
MIBK 5
Heparin 5
chromate 5
more...