Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.23 (
MMP
)
4,246
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
PRDM14
(PRDI-BF1 and RIZ domain-containing 14), a transcription factor, plays important roles in primordial germ cell specification and embryonic stem cell pluripotency, and supports the maintenance of self-renewal by promoting the expression of stem cell markers while also repressing the expression of differentiation factors. As a proto-oncogene, the ectopic expression of
PRDM14
can enhance breast cell growth and reduce breast cell sensitivity to chemotherapeutic drugs. Conversely, knockdown of
PRDM14
expression induces apoptosis in breast cancer cells and restores their sensitivity to chemotherapeutic drugs. Here, we sought to identify the role of
PRDM14
in 293T cells.
PRDM14
-infected 293T cells exhibited an abnormal morphology, and we found that ectopic expression of
PRDM14
inhibits colony formation, cell proliferation and metastasis. In addition, our data indicated that
PRDM14
influences the G1/S phase transition of 293T cells by inducing the expression of cell cycle regulators. In conclusion, these results showed that
PRDM14
inhibits 293T cell proliferation by influencing the G1/S phase transition and impacts cell migration by regulating the level of
MMP
/TIMP expression, thus mediating extracellular matrix degradation.
...
PMID:PRDM14 inhibits 293T cell proliferation by influencing the G1/S phase transition. 2769 12
