Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.23 (
MMP
)
4,246
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Overexpression of
transmembrane 4 L six family member 5
(
TM4SF5
), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of
TM4SF5
in migration, invasion, and tumor metastasis remain unknown. Using in vitro hepatocarcinoma cells that ectopically or endogenously express
TM4SF5
and in vivo mouse systems, roles of
TM4SF5
in metastatic potentials were examined. We found that
TM4SF5
expression facilitated migration, invadopodia formation,
MMP
activation, invasion, and eventually lung metastasis in nude mice, but suppression of
TM4SF5
with its shRNA blocked the effects. Altogether,
TM4SF5
-mediated migration and invasion suggest that
TM4SF5
may be therapeutically targeted to deal with
TM4SF5
-mediated hepatocellular cancers.
...
PMID:Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis. 2050 53
