Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.23 (
MMP
)
4,246
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A novel series of TNF-alpha convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of
L-tartaric acid
(tartrate) and coordinate to the active site zinc in a tridentate manner. They are selective for TACE over other
MMP
's. We report the first X-ray crystal structure for a tartrate-based TACE inhibitor.
...
PMID:The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. 2002 98
