Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.23 (
MMP
)
4,246
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum
apolipoprotein L1
(
APOL1
). Following uptake by endocytosis in the parasite,
APOL1
forms pores in endolysosomal membranes and triggers lysosome swelling. Here we show that
APOL1
induces both lysosomal and mitochondrial membrane permeabilization (LMP and
MMP
). Trypanolysis coincides with
MMP
and consecutive release of the mitochondrial TbEndoG endonuclease to the nucleus.
APOL1
is associated with the kinesin TbKIFC1, of which both the motor and vesicular trafficking VHS domains are required for
MMP
, but not for LMP. The presence of
APOL1
in the mitochondrion is accompanied by mitochondrial membrane fenestration, which can be mimicked by knockdown of a mitochondrial mitofusin-like protein (TbMFNL). The BH3-like peptide of
APOL1
is required for LMP,
MMP
and trypanolysis. Thus, trypanolysis by
APOL1
is linked to apoptosis-like
MMP
occurring together with TbKIFC1-mediated transport of
APOL1
from endolysosomal membranes to the mitochondrion.
...
PMID:Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1. 2630 71
