Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.23 (
MMP
)
4,246
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Non-peptidic inhibitors of
procollagen C-proteinase
(
PCP
) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds 89 and 60 have IC(50) values of 10 and 80 nM, respectively, against
PCP
; excellent selectivity over
MMP
's 1, 2, and 9; and activity in cell-based collagen deposition assays.
...
PMID:Design and synthesis of procollagen C-proteinase inhibitors. 2313 59
