Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.23 (
MMP
)
4,246
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
S100A14
is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. In this study, we characterized the regulation of
S100A14
expression between biological signatures and clinical pathological features in gastric cancer (GC). Our data demonstrated that
S100A14
induced the differentiation of GC by upregulating the expression of E-cadherin and PGII. Moreover,
S100A14
expression negatively correlated with cell migration and invasion in in vitro and in vivo experimental models. Interestingly,
S100A14
blocked the store-operated Ca
2+
influx by suppressing Orai1 and STIM1 expression, leading to FAK expression activation, focal adhesion assembly and
MMP
downregulation. Taken together, our results indicate that
S100A14
may have a role in the induction of differentiation and inhibition of cell metastasis in GC.
...
PMID:Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer. 2872 86
