Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.17 (MMP-3)
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Human Gene/Protein
ZNF510 13.2
matrix metalloproteinase 3 13.1
MMP-3 13.0
stromelysin 12.7
growth and transformation-dependent protein 12.2
SPBP 11.9
matrix metalloproteinase 10 11.6
MMP-1 11.3
ADAMTS-4 11.2
MMP-10 11.2
MMP-13 11.2
Cas-interacting zinc finger protein 11.2
MMP-11 11.1
MMP-25 11.1
MMP-19 11.0
MMP-27 10.9
DC32 10.9
metalloelastase 10.8
matrilysin 10.7
MT5-MMP 10.7
ADAMTS-5 10.7
MMP-7 10.6
Neurolysin 10.5
PLGL 10.5
UEF 10.5
stromelysin-3 10.5
Metalloelastase 10.4
ADAMTS-8 10.4
tissue inhibitor of metalloproteinases 10.4
MMP-12 10.3
MT4-MMP 10.2
Aggrecanase-1 10.2
TIMP-3 10.2
MMP-8 10.2
TIMP-2 10.2
TIMP 10.2
TIMP-4 10.1
MT2-MMP 10.0
Epilysin 10.0
MMP-23 10.0
Chondroadherin 10.0
leukolysin 10.0
collagenase-3 10.0
MMP-26 10.0
MMP-28 9.9
aggrecanase-1 9.9
ADAMTS15 9.8
ERp60 9.8
Type XIV collagen 9.7
E1A-F 9.7
matrix metalloproteinase 1 9.7
matrix metalloproteinase 2 9.7
MT1-MMP 9.7
MADA 9.6
TEL-2 9.6
transmembrane protease, serine 4 9.5
EDA protein 9.5
SFMBT2 9.5
MMP3 9.5
MMP-2 9.5
MMP-21 9.4
MMP-20 9.4
Insulin-like growth factor-binding protein 5 9.4
DEFA6 9.4
LOXL 9.4
MMP-9 9.3
MMP24 9.3
endopeptidase-2 9.3
cartilage intermediate layer protein 9.3
syndecan 3 9.3
ADAMTS4 9.3
Tissue factor pathway inhibitor-2 9.2
LGMN 9.2
TSR2 9.2
metalloproteinase 9.1
tissue inhibitor of metalloproteinase 1 9.1
epilysin 9.0
ADAM metallopeptidase domain 17 9.0
tissue inhibitor of metalloproteinases-2 9.0
MMP 9.0
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Disease
Mycoplasma arthritis 11.2
Corticosteroid-induced glaucoma 11.2
Canine elbow dysplasia 10.9
Tumor embolus 10.0
Biliary fibrosis 10.0
Cytotoxic edema 9.4
anaplastic osteosarcoma 9.4
Autoimmune myocarditis 9.3
cervical disc degeneration 9.0
Lumbar disc degeneration 8.9
RS3PE syndrome 8.4
benign proliferative breast disease 8.2
Steinbrocker 8.0
Mandibuloacral dysplasia 7.9
prostate cancer stage 7.9
facet joint degeneration 7.8
disc degeneration 7.7
Takahara 7.7
COL2A1 7.7
Tendinopathy 7.7
EBSS 7.6
degenerative disc disease 7.6
metastatic endometrial cancer 7.5
scleromalacia 7.5
inflammatory joint disease 7.4
Achilles tendinitis 7.4
Acute asthma 7.3
chondrolysis 7.2
Bone marrow edema 7.1
varicose ulcer 7.0
Pulmonary lymphangioleiomyomatosis 6.9
anetoderma 6.9
blepharochalasis 6.8
Neisseria gonorrhoeae infection 6.8
taste disorder 6.8
Peritoneal fibrosis 6.8
menopausal bleeding 6.8
Pseudopregnancy 6.6
osteoarthritis 6.5
Lequesne 6.5
Cardiovascular morbidity 6.5
MDK 6.5
Kashin-Beck disease 6.4
X-linked hydrocephalus 6.4
acroosteolysis 6.3
pulpitis 6.2
Lyme arthritis 6.2
IDD 6.2
bladder neoplasm 6.2
Intrauterine infection 6.2
Epidermolysis bullosa acquisita 6.1
ovarian serous cystadenocarcinoma 6.0
Recessive dystrophic epidermolysis bullosa 6.0
synovitis 6.0
CCL 5.9
Gingival overgrowth 5.9
herniated disc 5.9
PSN 5.9
Cardiac rupture 5.8
Dengue hemorrhagic fever 5.8
osteochondrodysplasia 5.6
MSS 5.6
degenerative disease 5.6
arthritis of the knee 5.6
rheumatoid arthritis 5.5
retrograde menstruation 5.5
Verrucous carcinoma 5.5
osteoblastic osteosarcoma 5.5
Prinzmetal 5.4
Chlamydia pneumoniae infection 5.4
premature aging 5.4
Malignant glioma 5.4
Pseudomonas infection 5.3
scleritis 5.3
Koebner 5.2
Pigmented villonodular synovitis 5.2
Pigmented villonodular synovitis 5.2
Spondyloarthritis 5.1
Tauopathies 5.1
sialidosis 5.1
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Symptom
Quadriceps weakness 8.9
Trembling 8.5
swollen joints 6.4
disturbed balance 6.4
skin damage 5.4
chronic back pain 3.6
arthralgia 3.4
neurological disability 3.3
DNA marker 3.3
knee pain 3.3
low back pain 3.2
dry skin 3.2
thinning 3.0
back pain 2.9
dry eye 2.8
bitter taste 2.7
erythema 2.3
Wind 1.8
angina 1.8
shoulder pain 1.7
cerebellar ataxia 1.4
functional recovery 1.1
hyperoxia 0.8
cachexia 0.7
pain 0.5
myalgia 0.5
collapse 0.4
spasm 0.3
distraction -0.0
weakness -0.0
respiratory distress -0.1
stigma -0.5
anorexia -0.6
acidity -0.7
hypothermia -0.9
headache -1.0
discomfort -1.3
cough -1.4
discomfort -1.4
starvation -1.4
overweight -1.5
analgesia -1.6
abdominal pain -1.7
anesthesia -2.6
seizures -3.1
Drug
Tanomastat 13.2
Prinomastat 10.0
Batimastat 9.7
Batimastat 9.7
Trimegestone 9.6
Marimastat 9.0
Pentosan polysulfate sodium 8.9
Avasimibe 8.6
Hirudoid 8.4
Tiaprofenic acid 8.2
Ilomastat 7.9
Gly-Tyr-Gly 7.8
Gelatin 7.6
Butaprost 7.2
Deflazacort 6.8
Bimatoprost 6.7
uPA 6.5
PNT 6.1
Nimesulide 6.0
CCL 5.8
SrCl2 5.8
BOTOX 5.8
Bexarotene 5.8
Tibolone 5.7
SrCl2 5.7
CIA 5.6
Abatacept 5.6
NOV 5.5
Doxycycline 5.4
ETS 5.4
Argatroban 5.3
Emodin 5.3
Arthrex 5.2
Adalimumab 5.1
Emodin 5.0
Myricetin 4.9
Gemfibrozil 4.8
Paraffin 4.7
Infliximab 4.6
Infliximab 4.6
SMP 4.6
TEL 4.6
Dextrose 4.6
Norplant 4.5
Cilostazol 4.5
Tocilizumab 4.5
ZnCl2 4.4
Finasteride 4.4
ZnCl2 4.4
Ramipril 4.4
IL-1ra 4.4
CVA 4.3
KGF 4.3
Retinoic acid 4.3
IL-11 4.1
CTX 4.0
CTX 4.0
Aloe 3.9
Oseltamivir 3.9
Urokinase 3.9
Budesonide 3.9
Pilocarpine 3.9
PDL 3.8
Raloxifene 3.7
G418 3.6
Asn 3.6
AGG 3.6
Simvastatin 3.5
ROS 3.4
Norplant 3.4
Bevacizumab 3.4
Aprotinin 3.3
DEX 3.3
Monensin 3.3
Isoniazid 3.3
Prednisone 3.2
CTX 3.2
-deoxyadenosine 3.2
MAP 3.2
FLP 3.1
more...
Enzyme
MMP-3 13.2
matrix metalloproteinase 10 11.5
interstitial collagenase 11.0
stromelysin-3 10.8
collagenase 3 10.7
neutrophil collagenase 10.5
deuterolysin 10.2
macrophage elastase 10.1
matrix metalloproteinase 2 9.8
aggrecanase-1 9.6
collagenase 9.5
matrix metalloproteinase 9 9.5
MMP 9.4
matrilysin-2 8.9
neurolysin 8.2
astacin 8.0
adamalysin 7.9
cathepsin G 7.3
carboxyl proteinase 7.0
TACE 6.9
heparitinase I 6.8
urokinase-type plasminogen activator 6.6
phosphatidylinositol phospholipase C 6.6
plasmin 6.6
Lys-gingipain 6.4
thermolysin 6.3
neutrophil elastase 6.2
hatching enzyme 6.2
hepsin 6.0
hepsin 6.0
NMT 5.8
chondroitin ABC lyase 5.7
caspase-10 5.7
TSR 5.7
KLK7 5.7
meprin 5.7
caspase-10 5.6
HCS 5.5
endoproteinase Glu-C 5.5
elastase 5.4
inositol 3-kinase 5.3
cathepsin L 5.2
endo-beta-galactosidase 5.2
chymase 5.1
chloramphenicol acetyltransferase 5.1
cathepsin B 5.1
tryptase 5.1
biliverdin reductase 5.1
TSP-1 5.0
thymidylate kinase 5.0
lysyl oxidase 4.9
tissue plasminogen activator 4.9
enterokinase 4.8
acrosin 4.8
SMP 4.8
type III procollagen 4.7
caspase-11 4.7
caspase-11 4.7
furin 4.7
insulin-degrading enzyme 4.7
nicotinamide phosphoribosyltransferase 4.7
matriptase 4.6
cathepsin C 4.6
galactocerebrosidase 4.5
mitogen-activated protein kinase 4.4
PHD 4.4
SCP 4.4
indoleamine 2,3-dioxygenase 4.3
carboxypeptidase A 4.2
prolidase 4.2
matriptase 4.2
kallikrein 4.2
thymidine phosphorylase 4.2
trypsin 4.1
HK2 4.1
PI-PLC 4.0
chymotrypsin 4.0
cathepsin D 4.0
prolyl hydroxylase 3.9
CD10 3.9
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Compound
C15H26O 12.2
C15H26O 12.2
C15H26O 12.2
C15H26O 12.2
C15H26O 12.2
C15H26O 12.2
C15H26O 12.2
C15H26O 12.2
C15H26O 11.6
C15H26O 11.6
C15H26O 11.6
alpha-Eudesmol 11.2
Himachalol 11.2
C15H26O 11.2
C15H26O 11.2
C15H26O 10.9
Globulol 10.9
C20H24O6 10.9
C15H26O 10.9
6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol 10.9
C6H12N2O 10.9
C15H26O2 10.6
Guaiol 10.4
Hydrangenol 10.4
Hinesol 10.4
Alizarin complexone 9.9
Chamazulene 9.9
Monotropein 9.7
4000 M 9.5
Tricetin 9.5
2,4-pyrimidinediamine 9.5
Azocoll 9.4
beta-Eudesmol 9.1
Isofraxidin 8.9
Cedrol 8.9
Collagenase 8.9
Stachydrine 8.7
C15H24 8.6
Eudesmol 8.3
Sinapic acid 8.2
Fangchinoline 8.2
Swertiamarin 8.2
Anserine 8.2
Tectorigenin 8.2
2,3-hexanedione 8.1
Patchouli alcohol 8.1
Sclareol 7.9
Stachydrine 7.9
Aucubin 7.8
Laminariaceae 7.8
Theaflavin 7.7
ETN 7.6
Myricitrin 7.5
Safranin O 7.5
Tricin 7.5
Decursin 7.5
Scoparone 7.4
Mycosporine 7.4
Sesamin 7.3
Safranin O 7.2
Acacetin 7.2
Plasmin 7.2
Loganin 7.1
Oleuropein 7.1
Nerolidol 6.9
Zingerone 6.9
Nerolidol 6.9
Pinocembrin 6.9
Butein 6.9
TACE 6.8
Myrcene 6.8
Pyridinoline 6.8
Diosmin 6.7
Nobiletin 6.7
Diethyl pyrocarbonate 6.6
Stanozolol 6.6
succinamide 6.6
Vitexin 6.6
Tyrosol 6.6
Stanozolol 6.5
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