Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.17 (
MMP-3
)
3,419
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
MMP-3
2358
stromelysin
1277
MMP-1
974
matrix metalloproteinase
818
MMP-9
771
MMP-2
693
collagen
621
collagenase
551
EPA
464
MMP-13
461
metalloproteinase
436
TIMP-2
279
IL-6
276
matrix metalloproteinase 2
249
Mol
233
cytokine
231
Sep
221
TNF
216
MMP
207
aggrecan
191
tissue inhibitor of metalloproteinases
185
matrix metalloproteinase 3
183
tumor necrosis factor
172
proteoglycan
163
fibronectin
160
MMP-7
144
MMP-8
138
MT1-MMP
132
IL-1
120
AP-1
112
MMP-10
112
IL-8
111
matrilysin
105
TIMP
101
p38
100
type II collagen
97
COX-2
94
ADAMTS-5
91
MMP-12
90
urokinase-type plasminogen activator
89
more...
Disease
tumor
362
osteoarthritis
356
cancer
338
rheumatoid arthritis
266
arthritis
197
tumor progression
94
atherosclerosis
71
carcinoma
70
metastases
59
breast cancer
56
plaque
45
disc degeneration
43
tumor growth
41
squamous cell carcinoma
38
synovitis
37
carcinogenesis
37
periodontitis
36
SDS
35
tumorigenesis
32
melanoma
31
diabetes
30
stroke
30
ischemia
29
arthropathy
28
adenocarcinoma
25
multiple sclerosis
25
Alzheimer's disease
22
prostate cancer
22
periodontal disease
21
autoimmune disease
21
hepatocellular carcinoma
21
myocardial infarction
20
degenerative disc disease
20
coronary artery disease
19
uterus
19
hypertension
19
COL2A1
17
MCF
17
lung cancer
17
chondrosarcoma
16
more...
Symptom
pain
40
back pain
10
thinning
10
low back pain
10
angina
8
arthralgia
8
skin damage
7
erythema
7
swollen joints
5
weakness
4
collapse
4
headache
3
functional recovery
3
knee pain
3
dry eye
2
respiratory distress
2
disturbed balance
2
anesthesia
2
Quadriceps weakness
1
chronic back pain
1
neurological disability
1
acidity
1
cachexia
1
anorexia
1
spasm
1
myalgia
1
seizures
1
discomfort
1
overweight
1
shoulder pain
1
DNA marker
1
starvation
1
abdominal pain
1
hyperoxia
1
discomfort
1
dry skin
1
Wind
1
Trembling
1
cough
1
hypothermia
1
more...
Drug
Dermatol
59
Gelatin
36
ROS
22
uPA
20
IFN-gamma
20
IL-2
15
MAP
15
Asn
15
CSF
15
ETS
12
lysine
11
CTX
10
Gel
10
CTX
10
CTX
10
Cardiovasc
10
Batimastat
8
Batimastat
8
Monit
8
CCL
8
Retinoic acid
7
Paraffin
6
ABC
6
ROC
6
Doxycycline
5
CIA
4
Indomethacin
4
Marimastat
4
Nephron
4
IL-1ra
3
Infliximab
3
PTH
3
Infliximab
3
ZnCl2
3
ZnCl2
3
G418
3
CaCl2
3
Nephron
3
CaCl2
3
CaCl2
3
more...
Enzyme
MMP-3
3419
collagenase
1389
MMP
302
matrix metalloproteinase 2
227
mitogen-activated protein kinase
224
interstitial collagenase
201
matrix metalloproteinase 9
167
urokinase-type plasminogen activator
115
plasmin
93
trypsin
78
ERK
72
protein kinase C
52
elastase
42
tissue plasminogen activator
36
neutrophil elastase
33
protein kinase
33
luciferase
30
neutrophil collagenase
30
cathepsin G
30
alkaline phosphatase
29
MEK
29
caspase-3
29
catalase
28
focal adhesion kinase
27
superoxide dismutase
26
stromelysin-3
25
reverse transcriptase
23
chloramphenicol acetyltransferase
19
chymotrypsin
19
thrombin
18
macrophage elastase
17
peroxidase
17
CD10
16
thermolysin
16
cathepsin B
15
kallikrein
12
matrix metalloproteinase 10
11
phospholipase A2
11
collagenase 3
11
transcriptase
10
more...
Compound
Dec
278
TNF
216
DNA
167
acetate
150
Clin
150
zinc
136
oxygen
85
serine
79
nitric oxide
78
calcium
65
leucine
60
sulfate
53
Collagenase
51
alanine
51
arginine
50
PGE2
48
PGE
48
Collagen
45
Gly
45
sodium
41
NH2
41
EDTA
40
EDTA
40
SDS
39
cysteine
37
retinoic acid
36
lysine
36
tyrosine
34
water
34
phosphate
30
glucose
27
MDA
26
Phe
26
hyaluronic acid
26
Asp
25
hydrogen
25
MTT
23
ASA
23
threonine
19
MEK
18
more...