Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.17 (MMP-3)
 3,419 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MMP-3 2358
stromelysin 1277
MMP-1 974
matrix metalloproteinase 818
MMP-9 771
MMP-2 693
collagen 621
collagenase 551
EPA 464
MMP-13 461
metalloproteinase 436
TIMP-2 279
IL-6 276
matrix metalloproteinase 2 249
Mol 233
cytokine 231
Sep 221
TNF 216
MMP 207
aggrecan 191
tissue inhibitor of metalloproteinases 185
matrix metalloproteinase 3 183
tumor necrosis factor 172
proteoglycan 163
fibronectin 160
MMP-7 144
MMP-8 138
MT1-MMP 132
IL-1 120
MMP-10 112
AP-1 112
IL-8 111
matrilysin 105
TIMP 101
p38 100
type II collagen 97
COX-2 94
ADAMTS-5 91
MMP-12 90
urokinase-type plasminogen activator 89
TIMP-3 89
MMP9 88
inducible nitric oxide synthase 84
type I collagen 83
TNF-alpha 72
MAPK 71
c-fos 69
p65 69
casein 63
elastin 61
PLA 61
ADAMTS-4 61
epidermal growth factor 59
ERK1 58
plasminogen 58
lipopolysaccharide 57
metalloprotease 56
JNK 56
MMP3 55
IL-10 54
interleukin-6 54
TGF-beta 53
c-Jun 51
vascular endothelial growth factor 50
ERK 49
cyclooxygenase-2 49
thrombospondin 47
collagenase-3 47
IL-1 beta 47
MMP-11 42
tumor necrosis factor alpha 40
p53 38
mitogen-activated protein 38
extracellular signal-regulated kinase 38
ras 37
IL-17 36
SDS 35
caspase-3 35
matrix protein 34
plasminogen activator inhibitor-1 33
osteopontin 32
C-reactive protein 31
E-cadherin 30
TIMP-4 30
matrix metalloproteinase 1 29
alkaline phosphatase 29
NMR 28
matrix metalloprotease 28
VEGF 28
IL-1 alpha 28
CRP 28
glycoprotein 28
stromelysin-3 27
cathepsin G 26
transforming growth factor-beta 26
platelet-derived growth factor 26
nerve growth factor 24
beta 1 24
MCP-1 24
chemokine 24
IL-4 24
Bcl-2 24
IFN 24
LPS 23
AKT 23
EGF 23
polypeptide 23
neutrophil elastase 22
ROS 22
hemopexin 22
Cytokine 22
cyclooxygenase 22
STAT3 21
ECM 21
PI3K 20
IFN-gamma 20
catenin 20
u-PA 19
MMP-19 19
insulin 19
MEK 19
MMP1 18
thrombin 18
COL2A1 17
RANKL 17
SOD 17
core protein 17
urokinase plasminogen activator 17
interleukin 6 16
Metalloproteinase 16
TPA 16
versican 16
vimentin 16
chymotrypsin 16
CAT 16
extracellular matrix metalloproteinase inducer 16
PKC 16
TIMP1 16
proto-oncogene 15
hairless 15
ESR 15
TLR4 15
HNE 15
MAP kinase 15
IL-2 15
decorin 15
GSH 15
cathepsin B 15
link protein 15
interferon-gamma 15
rheumatoid factor 15
nitric oxide synthase 14
matrix metalloproteinase 10 14
occludin 14
IL-13 14
superoxide dismutase 14
tenascin 14
tissue plasminogen activator 14
tyrosine kinase 14
mast cell 14
more...
Disease
tumor 362
osteoarthritis 356
cancer 338
rheumatoid arthritis 266
arthritis 197
tumor progression 94
atherosclerosis 71
carcinoma 70
metastases 59
breast cancer 56
plaque 45
disc degeneration 43
tumor growth 41
squamous cell carcinoma 38
carcinogenesis 37
synovitis 37
periodontitis 36
SDS 35
tumorigenesis 32
melanoma 31
diabetes 30
stroke 30
ischemia 29
arthropathy 28
multiple sclerosis 25
adenocarcinoma 25
Alzheimer's disease 22
prostate cancer 22
periodontal disease 21
hepatocellular carcinoma 21
autoimmune disease 21
myocardial infarction 20
degenerative disc disease 20
uterus 19
hypertension 19
coronary artery disease 19
MCF 17
COL2A1 17
lung cancer 17
chondrosarcoma 16
Blocking 15
skin cancer 15
colorectal cancer 15
GSH 15
degenerative disease 15
osteosarcoma 15
asthma 14
heart failure 14
obesity 14
inflammatory bowel disease 14
fibrosarcoma 14
glioma 14
liver fibrosis 13
lung carcinoma 12
Crohn's disease 12
endometriosis 12
infectious diseases 12
cornea 12
pheochromocytoma 12
colon cancer 11
Infection 11
cerebral ischemia 11
inflammatory joint disease 10
premature aging 10
cardiovascular disease 10
colitis 10
PCC 10
CTX 10
ulcerative colitis 9
glaucoma 9
Parkinson's disease 9
HIV 9
tumor angiogenesis 9
mammary tumor 9
systemic lupus erythematosus 9
cirrhosis 9
dysplasia 8
SAR 8
MIP 8
abdominal aortic aneurysm 8
acute myocardial infarction 8
SEM 8
CCL 8
bladder cancer 8
papilloma 8
glomerulonephritis 7
renal disease 7
ovarian cancer 7
glioblastoma 7
basal cell carcinoma 7
gastric cancer 7
ankylosing spondylitis 7
psoriatic arthritis 7
emphysema 7
psoriasis 7
primary tumor 7
leukemia 7
aggressiveness 7
encephalomyelitis 7
herniated disc 7
tuberculosis 7
diabetic nephropathy 7
coronary heart disease 7
vasculitis 6
PSS 6
invasive cancer 6
non-small cell lung cancer 6
scoliosis 6
pulmonary fibrosis 6
aqueous humor 6
sarcoma 6
bacterial meningitis 6
DBA 6
cardiomyopathy 6
dementia 6
pancreatic cancer 6
chronic obstructive pulmonary disease 6
osteoporosis 6
aortic aneurysm 6
scleroderma 6
epithelial tumor 6
pulpitis 5
hepatitis B 5
septic arthritis 5
tendinitis 5
chronic pancreatitis 5
neuroblastoma 5
chondrolysis 5
schwannoma 5
epidermolysis bullosa 5
glomerulosclerosis 5
astrocytoma 5
virus infection 5
benign tumor 5
bone metastases 5
type 2 diabetes 5
preeclampsia 5
celiac disease 4
migraine 4
dermatitis 4
dilated cardiomyopathy 4
lung metastases 4
chronic hepatitis 4
HSP 4
Dermal 4
renal cell carcinoma 4
cystic fibrosis 4
cognitive impairment 4
hyperglycemia 4
ductal carcinoma in situ 4
periosteum 4
chronic disease 4
thyroid cancer 4
intraocular pressure 4
Mycobacterium 4
arteriosclerosis 4
sepsis 4
myasthenia gravis 4
liver cancer 4
malaria 4
more...
Symptom
pain 40
back pain 10
thinning 10
low back pain 10
angina 8
arthralgia 8
skin damage 7
erythema 7
swollen joints 5
collapse 4
weakness 4
headache 3
knee pain 3
functional recovery 3
dry eye 2
respiratory distress 2
disturbed balance 2
anesthesia 2
Quadriceps weakness 1
chronic back pain 1
neurological disability 1
acidity 1
cachexia 1
anorexia 1
stigma 1
discomfort 1
bitter taste 1
dry skin 1
distraction 1
analgesia 1
overweight 1
shoulder pain 1
DNA marker 1
starvation 1
myalgia 1
spasm 1
cerebellar ataxia 1
seizures 1
abdominal pain 1
hyperoxia 1
discomfort 1
Wind 1
Trembling 1
cough 1
hypothermia 1
Drug
Dermatol 59
Gelatin 36
ROS 22
IFN-gamma 20
uPA 20
MAP 15
CSF 15
Asn 15
IL-2 15
ETS 12
lysine 11
CTX 10
Gel 10
Cardiovasc 10
CTX 10
CTX 10
Monit 8
CCL 8
Batimastat 8
Batimastat 8
Retinoic acid 7
ROC 6
ABC 6
Paraffin 6
Doxycycline 5
Indomethacin 4
Marimastat 4
CIA 4
Nephron 4
MRC 3
Infliximab 3
CaCl2 3
Infliximab 3
CaCl2 3
G418 3
Nephron 3
ZnCl2 3
IL-1ra 3
PTH 3
ZnCl2 3
CaCl2 3
Nimesulide 2
Tiaprofenic acid 2
Bevacizumab 2
IL-11 2
Simvastatin 2
Norplant 2
ascorbate 2
Emodin 2
ALA 2
Asthma 2
-deoxyadenosine 2
Norplant 2
Adalimumab 2
TEL 2
vitamin E 2
lactose 2
Dial 2
Prinomastat 2
Forskolin 2
Emodin 2
nitroglycerin 2
Aloe 2
Fluorescein 1
Pilocarpine 1
ETA 1
ENT 1
Gemfibrozil 1
Leaf 1
THF 1
Abatacept 1
DNase I 1
SrCl2 1
Monensin 1
Gly-Tyr-Gly 1
Vitamin A 1
Portal 1
PNT 1
AGG 1
Finasteride 1
Arthrex 1
Deflazacort 1
FLP 1
EE2 1
Tocilizumab 1
Pentosan polysulfate sodium 1
ADR 1
Rituximab 1
Prednisone 1
NOV 1
Tibolone 1
Angiotensin II 1
Bexarotene 1
Silica 1
Histamine 1
Dextrose 1
Glutathione 1
PDL 1
Glycyrrhiza 1
Budesonide 1
Vitamin E 1
KGF 1
Hirudoid 1
Isoniazid 1
ICI 1
Butaprost 1
BLM 1
CVA 1
BOTOX 1
Myricetin 1
Avasimibe 1
Raloxifene 1
Activin 1
caffeine 1
Trimegestone 1
Argatroban 1
Fragment 1
Oseltamivir 1
SrCl2 1
Ilomastat 1
DPA 1
DEX 1
Frontal 1
Urokinase 1
Aprotinin 1
Cilostazol 1
Tanomastat 1
Etoposide 1
Ramipril 1
SMP 1
Bimatoprost 1
Enzyme
MMP-3 3419
collagenase 1389
MMP 302
matrix metalloproteinase 2 227
mitogen-activated protein kinase 224
interstitial collagenase 201
matrix metalloproteinase 9 167
urokinase-type plasminogen activator 115
plasmin 93
trypsin 78
ERK 72
protein kinase C 52
elastase 42
tissue plasminogen activator 36
protein kinase 33
neutrophil elastase 33
luciferase 30
neutrophil collagenase 30
cathepsin G 30
MEK 29
caspase-3 29
alkaline phosphatase 29
catalase 28
focal adhesion kinase 27
superoxide dismutase 26
stromelysin-3 25
reverse transcriptase 23
chloramphenicol acetyltransferase 19
chymotrypsin 19
thrombin 18
macrophage elastase 17
peroxidase 17
CD10 16
thermolysin 16
cathepsin B 15
kallikrein 12
collagenase 3 11
phospholipase A2 11
matrix metalloproteinase 10 11
tryptase 10
glyceraldehyde-3-phosphate dehydrogenase 10
phospholipase C 10
TACE 10
RNA polymerase 10
transcriptase 10
AMP-activated protein kinase 9
furin 9
MAP 9
glutathione peroxidase 9
phosphatidylinositol 3-kinase 8
MIP 8
cathepsin L 8
caspase-9 8
pepsin 7
papain 7
cathepsin D 7
caspase-1 7
astacin 7
NO synthase 7
hyaluronidase 6
thymidine kinase 6
glyceraldehyde-3-phosphate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
IKK 6
RNase 6
RNase 6
proteasome 5
caspase-8 5
lactate dehydrogenase 5
beta-glucuronidase 5
glyceraldehyde-3-phosphate dehydrogenase 5
aggrecanase-1 5
glyceraldehyde-3-phosphate dehydrogenase 5
ornithine decarboxylase 5
PARP 5
chymase 5
heme oxygenase 5
NOS 4
AMPK 4
lipoprotein lipase 4
AMPK 4
ACE 4
lysyl oxidase 4
phosphoinositide 3-kinase 4
STR 3
cholesterol acyltransferase 3
calcineurin 3
prolyl hydroxylase 3
hyaluronidase 3
TSP-1 3
deuterolysin 3
chondroitinase 3
neurolysin 3
meprin 3
chondroitinase 3
indoleamine 2,3-dioxygenase 3
NADPH oxidase 3
cathepsin K 3
NADPH oxidase 3
ATPase 3
glutathione S-transferase 3
APC 2
ACS 2
chitinase 2
MAT 2
lysozyme 2
beta-galactosidase 2
acid phosphatase 2
carboxypeptidase A 2
prostate-specific antigen 2
adamalysin 2
phosphoglucose isomerase 2
insulin-degrading enzyme 2
endoproteinase Glu-C 2
enterokinase 2
CAD 2
HCS 2
CAD 2
ceruloplasmin 2
tissue kallikrein 2
CAD 2
transglutaminase 2
paraoxonase 2
paraoxonase 2
type III procollagen 2
DNA methyltransferase 2
PHD 2
MAT 2
prostaglandin synthetase 2
thymidine phosphorylase 2
SMP 2
alanine aminotransferase 2
endo-beta-galactosidase 2
acrosin 2
glutamine synthetase 2
renin 2
mu-calpain 1
m-calpain 1
hepsin 1
MEKK1 1
SCP 1
matrilysin-2 1
GSK 1
caspase-10 1
caspase-11 1
NMT 1
matriptase 1
demethylase 1
PNGase F 1
neuraminidase 1
HK2 1
adenylate cyclase 1
carboxypeptidase Y 1
porphobilinogen deaminase 1
caspase-10 1
phosphatidylinositol phospholipase C 1
TSR 1
dipeptidyl peptidase IV 1
KLK7 1
caspase-11 1
more...
Compound
Dec 278
TNF 216
DNA 167
acetate 150
Clin 150
zinc 136
oxygen 85
serine 79
nitric oxide 78
calcium 65
leucine 60
sulfate 53
Collagenase 51
alanine 51
arginine 50
PGE2 48
PGE 48
Collagen 45
Gly 45
sodium 41
NH2 41
EDTA 40
EDTA 40
SDS 39
cysteine 37
lysine 36
retinoic acid 36
tyrosine 34
water 34
phosphate 30
glucose 27
hyaluronic acid 26
Phe 26
MDA 26
hydrogen 25
Asp 25
ASA 23
MTT 23
threonine 19
methionine 18
Ile 18
MEK 18
TPA 16
TPA 16
CAT 16
GSH 16
CAT 16
CAT 16
GSH 16
Cardiol 15
THP 13
Curcumin 13
His 13
cAMP 13
THP 13
Plasmin 12
AMP 12
salt 12
Safranin O 12
PMA 12
PMA 11
nitrogen 11
bromide 11
MAP 11
Dexamethasone 11
galactose 11
urea 10
proline 10
TACE 10
CTX 10
CCP 10
tryptophan 9
tryptophan 9
N-acetylcysteine 9
COS 9
Cereb 9
tryptophan 9
DBA 9
tryptophan 9
DMSO 8
silver 8
ethanol 8
ATP 7
Progesterone 7
methanol 6
Phorbol 6
keratan sulfate 6
pyrrolidine 6
pyrrolidine 6
DBA 6
Safranin O 6
DBA 6
D-glucosamine 6
asparagine 5
glutamic acid 5
Insulin 5
glutamate 5
Heparin 5
aspartic acid 5
Glucosamine 5
pyrimidine 5
TNM 5
SCC 5
vitamin D 5
PEG 5
Casein 5
Doxycycline 5
acrylamide 5
PEG 5
Resveratrol 5
pyrimidine 5
dUTP 5
copper 5
cobalt 5
acetic acid 5
COX 5
Azocoll 5
Thrombin 4
Ascorbic acid 4
Panam 4
piperazine 4
Neo 4
NMDA 4
glycerol 4
aspartic acid 4
retinol 4
benzene 4
HgCl2 4
GTP 4
ammonium 4
Rapamycin 4
anthracene 4
iodine 4
creatinine 4
Hematoxylin 4
aspartic acid 4
PAR 4
aspartic acid 4
Elastin 4
Berberine 3
potassium 3
Trypsin 3
CO2 3
Alendronate 3
Triton X-100 3
Cyclosporine 3
Sesamin 3
5-HT 3
Crocin 3
homocysteine 3
DEAE 3
TCA 3
glutamine 3
Oleic acid 3
Alendronate 3
dCTP 3
PDB 3
Vitamin D 3
CaCl2 3
kaempferol 3
more...