Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.17 (
MMP-3
)
3,419
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The receptor tyrosine kinase
AXL
promotes migration, invasion, and metastasis. Here, we evaluated the role of
AXL
in endometrial cancer. High immunohistochemical expression of
AXL
was found in 76% (63/83) of advanced-stage, and 77% (82/107) of high-grade specimens and correlated with worse survival in uterine serous cancer patients. In vitro, genetic silencing of
AXL
inhibited migration and invasion but had no effect on proliferation of ARK1 endometrial cancer cells.
AXL
-deficient cells showed significantly decreased expression of phospho-AKT as well as uPA, MMP-1, MMP-2,
MMP-3
, and MMP-9. In a xenograft model of human uterine serous carcinoma with
AXL
-deficient ARK1 cells, there was significantly less tumor burden than xenografts with control ARK1 cells. Together, these findings underscore the therapeutic potentials of
AXL
as a candidate target for treatment of metastatic endometrial cancer.
...
PMID:AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer. 2776 92
