Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.17 (MMP-3)
 3,419 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

EFEMP2 is an extracellular matrix (ECM) glycoprotein that is a pivotal oncogene in tumor progression and metastasis. However, the function of EFEMP2 in colon cancer remains unknown. In this study, we found that EFEMP2 was highly expressed in colon cancer cells. Knockdown of EFEMP2 suppressed the growth and invasion of colon cancer LoVo and SW620 cells. Moreover, knockdown of EFEMP2 attenuated ERK1/2 activation, as well as decreased MMP-3 expression. Taken together, our study demonstrates that EFEMP2 is significantly expressed in colon cancer cells. EFEMP2 can promote the growth and invasion of colon cancer cells, possibly by regulation of ERK1/2 activation and MMP-3 expression. Therapies targeting EFEMP2 may be an effective strategy for treatment of colon cancer.
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PMID:EFEMP2 promotes colon cancer cell invasion and growth through the ERK1/2 signaling pathway. 3193 93