Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.17 (
MMP-3
)
3,419
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Homeobox genes (HOX genes) have been implicated in many tumors. As a member of HOX genes,
HOXB5
is overexpressed in bladder cancer and contributes to the proliferation and invasion of breast cancer cells. However, functions of
HOXB5
in retinoblastoma remain elusive. In this study, we found that
HOXB5
expression is upregulated in retinoblastoma cell lines and tissues. Overexpression of
HOXB5
promoted retinoblastoma cell migration and invasion, but knockdown of
HOXB5
suppressed the migration and invasion. Moreover,
HOXB5
induced the activation of ERK1/2 and upregulated the production of
MMP-3
and MMP-13. In addition, ERK1/2 pathway was required for
HOXB5
-mediated retinoblastoma cell migration and invasion. Taken together, our study suggests that
HOXB5
promotes the migration and invasion of retinoblastoma cells by inducing the activation of ERK1/2 and increasing the production of
MMP-3
and MMP-13. Therefore,
HOXB5
may represent an effective target for treatment of retinoblastoma.
...
PMID:HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-mediated MMPs production. 3001 11
