Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.17 (
MMP-3
)
3,419
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An Ets-related
E1A-F
has been characterized as an enhancer-binding protein for the adenovirus E1A gene. Here we show, in transient expression assays, that
E1A-F
can activate three different subclasses of the matrix metalloproteinase gene promoters. Expressions of the chloramphenicol acetyltransferase (CAT) reporter gene under the control of
stromelysin
, type I collagenase and 92 kD type IV collagenase promoters were increased approximately 10- to 20-fold by co-transfection with the
E1A-F
expression vector. Activation levels were as much high as those obtained by exogenous expression of AP-1 transcription factor. These results suggest that
E1A-F
positively regulates transcriptions from matrix metalloproteinase genes that are associated with invasion and metastasis of tumor cells.
...
PMID:Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters. 773
