Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.11 (CD10)
 9,792 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cutaneous angiomyolipoma is a rare mesenchymal tumor, distinct from its renal counterpart. Only few cases have been reported in English language literature to date. Here, we report a case in a 36-year-old man who presented with a painless swelling on his right ear. Microscopy revealed a well-circumscribed tumor, composed of an admixture of mature adipocytes, blood vessels, and bundles of smooth muscles. The tumor cells were positive for desmin and calponin but negative for HMB45, melan-A, SOX10, tyrosinase, and CD10. We present the case to emphasize the uniqueness of cutaneous angiomyolipoma from its renal counterpart. We also review the relevant literature on this topic.
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PMID:Cutaneous Angiomyolipoma of the Ear: A Case Report and Literature Review. 3134 26

Intraductal papillary neoplasm of breast (IDPN) belongs to a pathological heterogeneous group of diseases, which spans the spectrum of benign, atypical, and malignant. It constitutes less than 10% of benign breast lesions and less than 1% of malignant breast cancers. The majority of IDPNs begins within the ductolobular system of the breast and shows cystic structure with intracystic finger-like projection containing fibrovascular cores. The reasons that made the diagnosis of IDPNs difficult were the proliferation of breast epithelium and the emergence of some illusions. We systematically reviewed 47 cases of breast IDPNs, including 19 cases of intraductal papilloma (IDP), 2 cases of intraductal papilloma with atypical ductal hyperplasia (IDP with ADH), 4 cases of intraductal papilloma with ductual carcinoma in situ (IDP with DCIS), 22 cases of intraductal papillary carcinoma (IDPC), and underwent p63, CD10, SMA, calponin, CK5/6, ER immunohistochemistry Envision staining analysis. This study was focused on three cases which were easy to misdiagnosis and combined the WHO classification to sort out the pathological changes, arousing attention in daily pathological diagnosis.
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PMID:Clinicopathologic features of intraductal papillary neoplasm of breast: analyses of three cases. 3196 34


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