Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.24.11 (CD10)
 9,792 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Enzyme electrophoresis was used to compare the isozyme phenotypes of Oryza sativa, IR31917 (AA genome), and two O. minuta accessions (Om 101089 and Om101141; BBCC genome) for ten enzyme systems. Between the two species, two systems were monomorphic (isocitrate dehydrogenase and alcohol dehydrogenase) and eight were polymorphic (shikimate dehydrogenase, phosphogluconate dehydrogenase, phosphoglucose isomerase, malate dehydrogenase, glutamate oxaloacetate transaminase, esterase, aminopeptidase, and endopeptidase). Polymorphism between O. minuta accessions was detected for shikimate dehydrogenase and glutamate oxaloacetate. As expected, the quaternary structure of the O. minuta isozymes was comparable to that of O. sativa. Possible allelic relationships with known O. sativa alleles and their genomic designation are discussed. Combined with chromosome data, the interspecific variation was exploited to monitor the relative genetic contribution of the two parents in the IR31917/Om101141 F1 hybrids and recurrent (IR31917) backcross progenies. The isozyme content of F1 hybrid reflected its triploid nature (ABC genome composition), while that of the backcross progenies paralleled the duplication of the A genome and the gradual loss of O. minuta chromosomes during the backcrossing process. Evidence is provided for a degree of homoeology between the A, B, and C genomes, and for introgression from O. minuta into O. sativa.
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PMID:Comparative studies of isozymes in Oryza sativa, O. minuta, and their interspecific derivatives: evidence for homoeology and recombination. 2419 Mar 57

Intraductal papillary neoplasm of breast (IDPN) belongs to a pathological heterogeneous group of diseases, which spans the spectrum of benign, atypical, and malignant. It constitutes less than 10% of benign breast lesions and less than 1% of malignant breast cancers. The majority of IDPNs begins within the ductolobular system of the breast and shows cystic structure with intracystic finger-like projection containing fibrovascular cores. The reasons that made the diagnosis of IDPNs difficult were the proliferation of breast epithelium and the emergence of some illusions. We systematically reviewed 47 cases of breast IDPNs, including 19 cases of intraductal papilloma (IDP), 2 cases of intraductal papilloma with atypical ductal hyperplasia (IDP with ADH), 4 cases of intraductal papilloma with ductual carcinoma in situ (IDP with DCIS), 22 cases of intraductal papillary carcinoma (IDPC), and underwent p63, CD10, SMA, calponin, CK5/6, ER immunohistochemistry Envision staining analysis. This study was focused on three cases which were easy to misdiagnosis and combined the WHO classification to sort out the pathological changes, arousing attention in daily pathological diagnosis.
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PMID:Clinicopathologic features of intraductal papillary neoplasm of breast: analyses of three cases. 3196 34