Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.11 (CD10)
 9,792 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of cutaneous malignant lymphoma in a 7-month-old infant is described. The skin was the only apparent organ involved. Immunophenotypic studies revealed that the infiltrate was positive for B4 (CD19), J5 (CD10), and cytoplasmic mu chain, and lambda chain, but negative for B1 (CD20). The significance of these findings is discussed. We believed the tumor was of B-cell origin. The reported cases of cutaneous malignant lymphoma in infancy are briefly reviewed.
J Dermatol 1990 Dec
PMID:Cutaneous malignant lymphoma in an infant. 208 21

The clinical and pathological findings in a patient with monocytic aleukemic leukemia presenting initially as multiple monoblastic tumors of the skin is described. The patient was a 35-year-old Japanese woman, who had first noticed multiple, asymptomatic, reddish-brown papules on her trunk. Asymptomatic enlargements of several lymph nodes were present in the bilateral cervical and axillary areas. There was no hepatosplenomegaly, sternal tenderness, bruising, or bleeding. The skin and lymph node biopsies were originally interpreted as malignant lymphoma. The diagnosis of acute monocytic leukemia was established when bone marrow involvement was detected. Immunohistochemical observation of the skin eruptions revealed the following: Positive staining with lysozyme was noted in almost half of the infiltrating atypical cells. Most of the infiltrating cells reacted positively with antisera to Leu-M5 and some of them reacted to Leu-M1. The helper T cell antibody, Leu-3a+3b, showed weak positive staining of most infiltrating cells. However, there were no reactions with antisera to Leu-6, Leu-7, Leu-14, CALLA, OKT 6, OKT 8, OKT 16, OKB 19, OKM 14, beta F1, or delta TCS1. OKM 5-positive keratinocytes were observed in some parts of the upper epidermis, although no OKM 5 expression could be detected on any tumor cells. Cytochemistry, immunohistochemistry, and electron microscopy can aid in the diagnosis of monocytic leukemia. This case illustrates the importance of using an expanded panel of monoclonal antisera in certain hematopoietic tumors.
J Dermatol 1990 Oct
PMID:Cutaneous involvement as a presenting feature of monocytic leukemia: morphological and immunohistochemical studies. 227 62

We present evidence that enzyme activity hydrolyzing Succinoyl trialanine paranitroanilide (Suc(Ala)3NA) expressed by Human Skin Fibroblasts (HSF) in culture could be attributed to the concerted action of an endopeptidase and an aminopeptidase(s). Both endopeptidase and aminopeptidase activities were strongly inhibited by metal chelating agents and Copper and Zinc ions but were insensitive to Tissue Inhibitor of Metallo Proteases (TIMP). These protease activities coeluted on ion exchange chromatography (DEAE Tris acryl M) and were further separated by high-performance liquid chromatography HPLC (TSK 3000 SW). The endopeptidase activity, designated as HSF E1, was eluted at the position corresponding to an Mr equal to 94,000. It has only a limited elastinolytic potential as evaluated on 3H insoluble elastin, but it extensively degrades human skin elastic fibers as directly assessed on human skin tissue sections and further quantitated by automated image analysis. The level of HSF E1 increases with the number of fibroblast passages.
J Invest Dermatol 1988 Nov
PMID:Characterization of human skin fibroblasts elastase activity. 304 35

The immune phenotype of the infiltrating cells in 13 positive patch tests from 8 cases of contact dermatitis and 1 case of poison ivy was studied. An indirect immunoperoxidase technique was used in conjunction with monoclonal antibodies directed against mature T cells (Leu-1, T11), helper T cells (Leu-3A), suppressor/cytotoxic T cells (Leu-2A), killer and natural killer cells (HNK 1), B cells (B1), Langerhans cells (HLA-DR), and the common acute lymphoblastic leukemia antigen (CALLA), (J5). The majority of infiltrating mononuclear cells were Leu-1+, T11+, Leu-3A+, Leu-2A-, HLA-DR+, T9-, T10-, HNK-, B1-, J5-. Occasional T6+ cells were observed in the epidermis (including spongiotic microvesicles) and also isolated in the dermis and within the dermal mononuclear infiltrates. The phenotype was compared with cutaneous T-cell lymphoma, a disease in which contact allergy and antigenic persistence may play a role.
J Invest Dermatol 1985 Mar
PMID:Immunophenotype of lymphoid cells in positive patch tests of allergic contact dermatitis. 315 92

Succinyl-trialanine paranitroanilide, a specific synthetic substrate of elastases, was shown to be hydrolyzed by Triton X-100 extracts of human skin fibroblasts at near neutral pH. The neutral endopeptidase has been partially purified by ion exchange chromatography (DEAE Sephadex) and affinity chromatography using an AH-Sepharose (Ala)3 column. The enzyme has been purified 85-fold and appears to be a metalloprotease as shown by its inhibitory profile. In its partially purified form, the neutral endopeptidase was found inactive toward benzoyl arginine paranitroanilide, benzoyl tyrosine paranitroanilide, azocasein, type I collagen, and [3H]ligamentum nuchae-insoluble elastin. Structural glycoprotein microfibrils isolated from porcine aorta are extensively degraded by this neutral protease. It could also hydrolyze, but to a lesser extent, insoluble elastin purified from human aortas; it was, however, found inactive toward bovine ligamentum nuchae elastin. Its potentiality to degrade the human skin elastic fiber system (namely elastic fibers, oxytalan, and elaunin fibers) has been assessed by a morphometric analysis of the length of these fibers (on tissue sections appropriately stained to identify the components of the elastic fiber system) prior to and after enzyme action. Analysis of the data obtained by morphometry indicated that this neutral protease attacked rapidly both elaunin and oxytalan fibers of human dermis, but only slowly the mature elastic fibers.
J Invest Dermatol 1984 Sep
PMID:On the presence of a metalloprotease in human skin fibroblasts that degrades the human skin elastic fiber system. 638 8

An aminoendopeptidase isolated from 2-day-old rat epidermis was purified to apparent homogeneity by the procedures of ammonium sulfate fractionation, DE-52 column chromatography, Sephadex G-200 gel filtration, and CM-52 and DEAE-Sepharose 6B column chromatography. Enzymatic activity was exhibited only in the presence of sulfhydryl compounds and further enhanced by addition of 5 mM EDTA. It was inhibited by p-chloromercuribenzoate, other sulfhydryl blocking reagents, and o-phenanthroline. The monomer form of the enzyme is Mr = 52,000 +/- 2,300 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis, but a native form was considered to be Mr = 400,000 +/- 26,000 having an isoelectric point of pH 5.25. Among synthetic substrates the enzyme hydrolyzed amino acid 2-naphthylamide derivatives and L-leucine amine (L-LeuNH2) most effectively. N-alpha-benzoyl-DL-arginine-2-naphthylamide (BANA) was the only endopeptidase substrate for the enzyme and a competitive inhibitor for its aminopeptidase activity. Protein substrates have not yet been found. The pH optimum is 7.5 and in a range of pH 6.5-7.5 it is stable at 37 degrees C for 30 min but loses about 50% of its activity at 50 degrees C.
J Invest Dermatol 1984 Oct
PMID:Purification and properties of aminoendopeptidase from rat epidermis. 638 76

A case of cutaneous B-cell lymphoma successfully treated by MACOP-B therapy is described. The patient was a 43-year-old man with reddish tumors measuring 3 to 7 cm in diameter on the right cheek and the post-auricles. Histopathologically, massive infiltrations of medium-sized atypical lymphoid cells were found in the reticular dermis and subcutis. A clear zone beneath the epidermis was also detected. The atypical lymphoid cells were positive for CD19, CD20, CD22 and HLA-DR but negative for CD3, CD4, CD5, CD10, CD43, CD45RO and CDw75. The patient was treated successfully with the MACOP-B protocol from March of 1990 to May of 1990. Since April of 1990, he has been free of disease.
J Dermatol 1993 Jan
PMID:A case of cutaneous B-cell lymphoma treated successfully with MACOP-B. 768 13

In lymphoproliferative diseases of the skin, DC have a key role in T- and B-cell homing. Furthermore, DC alterations may have a pathogenic role in the natural history of specific disorders, either in the neoplastic lymphoid cell progression or in antitumoral lymphocyte reaction. Finally, the morphoantigenic and topographic features of DC may have diagnostic and histogenetic relevance in specific conditions. In CTCL, dermal CD1a+ DC ("indeterminate cells") seem to play a significant role in the neoplastic progression of MF, whereas the possible pathogenetic role of specific alterations of epidermal LC is yet to be proven. Recently, a possible implication of DD (resident, perivascular factor XIIIa+/CD1a- DC) in the pathogenesis of MF has been also suggested. The presence and possible significance of DC in CTCL non-MF are presently poorly studied. At present, DC number, distribution, and phenotype seem possibly useful in the differential diagnosis between CTCL and pseudo-CTCL, but this hypothesis has to be adequately confirmed. CBCL has been recently proposed as a unique type of clinically low-grade lymphoma, namely, skin-associated lymphoid tissue (SALT)-related B-cell lymphoma. Both SALT- and mucosa-associated lymphoid tissue (MALT)-related B-cell lymphoma share with a peculiar nodal lymphoma of follicle mantle origin (parafollicular-monocytoid lymphoma) the nonaggressive clinical behavior and the uniform phenotype (CD5-, CD10-) and genotype (lack of bcl-2 gene rearrangement) of neoplastic B cells, despite the wide variability of cytomorphologic appearances. The putative origin of CBCL is further supported by the typical CD14-, nerve growth factor receptor (NGFr)+ immunophenotype of DRC. Moreover, the immunophenotype and architectural fashion of DRC are interesting clues to the differentiation between neoplastic and true reactive folliclelike nodules and may be of help in the differential diagnosis between CBCL and B-cell pseudolymphoma as well as in the correct interpretation of lesions showing monoclonal proliferations of B cells accompanied by polyclonal follicular reactions.
Dermatol Clin 1994 Apr
PMID:Dendritic cells in T- and B-cell proliferation in the skin. 804 37

Eleven cases of cutaneous B-cell lymphoma (CBCL) were studied. The ages at presentation ranged from 34 to 79 years (mean = 59.9 years). Six patients were female and five male. Five of the 11 patients had a solitary tumour and the other six had multiple tumours at initial presentation. According to Burg's classification, six cases were at stage I, two stage II, two stage III and one was at stage IV at initial presentation. Abnormalities in laboratory data were rare, except for serum lactic dehydrogenase values. Epidermotropism was not detected, and the area mainly affected by neoplastic cells was the reticular dermis (seven cases) and subcutis (four cases). Biopsy specimens from the patients analysed by immunohistochemical techniques on paraffin or cryostat sections showed CD20 and/or CD22 positivity. Biopsy specimens from two patients which showed CD10 positivity were diffuse large cell types by the working formulation and presented as pre-B-cell lymphoma. At least two groups of CBCL were demonstrable on the basis of prognosis. One was a benign low-grade lymphoma presenting with solitary tumours, mature B-cell markers and intermediate-grade pathology, and the other was a high-grade lymphoma with multiple tumours, pre-B-cell or mature B-cell markers and a poor prognosis.
Clin Exp Dermatol 1993 Nov
PMID:Cutaneous B-cell lymphoma--a clinical, pathological and immunohistochemical study. 825 90

Neuropeptides make up one of the largest and functionally most diverse groups of signaling molecules. They exert their effects by interacting with members of the large family of G-protein-coupled receptors, which transmit information about the extracellular environment to the interior of the cell by interacting with the heterotrimeric G-proteins. Cellular responses to neuropeptides are usually rapidly attenuated. Mechanisms of signal attenuation include removal of peptides from the extracellular fluid and receptor desensitization. Peptides are removed from the extracellular fluid principally by enzymatic degradation by cell surface enzymes, exemplified by neutral endopeptidase. Receptor desensitization is mediated by receptor phosphorylation by G-protein receptor kinases and second messenger kinases, interaction of receptors with arrestins, and consequent receptor uncoupling from G-proteins. Peptides also induce endocytosis of their receptors, which may contribute to desensitization by depleting the cell surface of high-affinity receptors. Recycling and processing of internalized receptors, which include dissociation of receptors from their ligands and receptor dephosphorylation, contribute to resensitization of cellular responses. These regulatory mechanisms are important for they determine the ability of cells to respond to agonists, and defects may result in uncontrolled stimulation of cells, which could cause disease. A greater understanding of the processes that modulate signaling by neuropeptides may lead to the development of novel receptor antagonists and agonists and help to explain the mechanism of drug tolerance.
J Investig Dermatol Symp Proc 1997 Aug
PMID:Mechanisms attenuating cellular responses to neuropeptides: extracellular degradation of ligands and desensitization of receptors. 948 19


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