Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.11 (CD10)
 9,792 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In Indonesia, 107 women requesting insertion of the contraceptive implant system Norplant at the Klinik Raden Saleh in Jakarta kept a daily menstrual diary for 90 days before endometrial biopsy and allowed venous blood samples to be taken six times in the two-week period also before endometrial biopsy so researchers could examine the roles of endothelin (ET) and neutral endopeptidase (NEP) in menstrual bleeding changes in women using Norplant. They compared the degree of immunostaining in the endometrial biopsy samples of these women with those of 55 controls, most of which came from women in Melbourne, Australia. The endometrium of the Norplant group exhibited low glandular and luminal epithelial ET immunostaining as did the normal endometrium during the proliferative phase. Glandular epithelial ET immunostaining in the Norplant group fell considerably during the secretory or menstrual phases, however. NEP immunoreactivity was greater in the endometrium of Norplant users than in that of controls, suggesting that enzyme activity may have been increased locally among Norplant users. This increase may have accounted for the low ET reactivity. ET immunoreactivity was not related to duration of implant use or total number of bleeding days. These findings indicate that, since Norplant users are at an increased risk of abnormal uterine bleeding, ET may control menstrual bleeding. It is not known whether ET acts as a mitogen in endometrial repair and regeneration or as a vasoconstrictor to stop bleeding after menstruation.
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PMID:Immunolocalization of endothelin and neutral endopeptidase in the endometrium of users of subdermally implanted levonorgestrel (Norplant). 856 75