Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
Compound
Query: EC:3.4.24.11 (
CD10
)
9,792
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Shadow cell differentiation (SCD), commonly found in cutaneous pilomatricoma (PMX), has been said to be extremely rare in extracutaneous tumors and its morphogenesis has not been clarified yet. In the present study, 25 cases of
endometrial adenoacanthoma
were examined with special reference to SCD and with immunohistochemistry for beta-catenin and
CD10
. Shadow cell nests (SCNs) were observed in 2 out of 5 cases of adenocarcinoma with squamoid morules and all of 4 cases of adenocarcinoma with squamous differentiation and morules, but not in any cases of adenocarcinoma with squamous differentiation. SCNs were just adjacent to morules with or without a mutual transition. Immunohistochemical examination revealed nuclear accumulation of beta-catenin and expression of
CD10
in the squamoid morules around SCNs. These results indicate that SCNs are derived from squamoid morules in
endometrial adenoacanthoma
, and established a link between matrical basaloid cells in PMX and squamoid morules in
endometrial adenoacanthoma
, as common original tissues, showing nuclear accumulation of beta-catenin and expression of
CD10
, of SCNs. It seems that SCD is not so uncommon as previously estimated in
endometrial adenoacanthoma
.
...
PMID:Shadow cell differentiation from squamoid morule in endometrial adenoacanthoma. 2672 10
