Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.11 (CD10)
 9,792 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The WSU-NHL cell line was established from a malignant pleural effusion occurring in a 46-yr-old female with nodular histiocytic (follicular, large cell) lymphoma. The established cells grow in clumps with a doubling time of 57 h. On light microscopy, cells exhibited primitive lymphoblastoid morphologic features with few cytoplasmic blebs. DNA histogram generated by flow cytometry indicated a hypodiploid stemline (0.93). Immunologic study revealed a mature B-cell phenotype with surface and cytoplasmic IgG lambda and reactivity with monoclonal antibodies to B-cell antigens (B1, B4, BL1, BL3, BL4, BL7, HLA-DR, CALLA and Leu-10). The cells were negative for T-cell and myeloid-monocyte antigens as well as Epstein-Barr virus nuclear antigen (EBNA). Cytogenetic analysis revealed 45,XX metaphases with complex abnormalities including t(14;18) (q32;q21). The phorbol ester, 12-O tetradecanoylphorbol 13 acetate (TPA) (1.6 x 10(-8) M) and interferon gamma (IFN-gamma) (500 U/ml) inhibited cell growth and induced differentiation to a more mature phenotype. The WSU-NHL cell line provides a continuous source of cells for molecular and immunologic studies of human lymphoma as well as the regulation of its growth and differentiation by biologic agents.
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PMID:Establishment and characterization of a human lymphoma cell line (WSU-NHL) with 14;18 translocation. 314 65

Pleural effusions and mediastinal masses are associated with certain types of hematologic malignancies. We report a 20-year-old man with a pleural effusion, a mediastinal mass, and a normal hemogram. The cytology of the pleural effusion initially suggested a lymphoma. However, an immunophenotypic study of the effusion revealed the following: TdT+, CD34+, CD19+, CD7(-), CD33(-), CD10(-), sIgM(-), and positive cytoplasmic mu heavy-chain immunoglobulins. After a bone marrow examination, we diagnosed the patient with pre-B acute lymphoblastic leukemia (ALL). This is the first reported case of a malignant pleural effusion and a mediastinal mass that preceded pre-B ALL. After standard therapy for ALL, the patient has been disease-free for 7 years.
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PMID:Mediastinal mass and malignant pleural effusion in an aleukemic case with pre-B acute lymphoblastic leukemia. 1919 2

Malignant effusions because of renal-cell carcinoma (RCC) are an unusual event and occur in patients with papillary and clear cell tumors. We have studied a 65-year-old man who underwent right renal tumorectomy, diagnosed as chromophobe RCC (pT1). After 16 months, the patient presented cough and fever. Positron emission computed tomography demonstrated extensive mediastinal lymphadenopathy. Chest radiograph showed right pleural effusion. The cytological examination of the fluid showed malignant cells. Immunohistochemistry had been performed on primary renal tumor and on cell block of pleural effusion. The renal tumor showed positivity for parvalbumin, cytokeratin (CK) 7, C-kit (CD117), E-cadherin, and RCC marker. The neoplastic cells of pleural effusion showed positive immunohistochemical staining for parvalbumin, RCC marker, pancytokeratin, epithelial membrane antigen, CK7, C-kit (CD117), E-cadherin, and CD10. They were negative for thyroid transcription factor-1, CK20, calretinin, CK5, D2-40 podoplanin, CDX2, and Wilms' tumor suppressor gene. Malignant effusion secondary to RCC is rare. In several studies, RCC had been the cause of 1-2.2% of malignant pleural fluids. Chromophobe RCC tends to be localized into the kidney and to be of nuclear grade 2 at presentation, factors that probably explain its more favorable outlook. In our case, the chromophobe RCC was asymptomatic and was discovered because abdominal pain due to stone in the gallbladder. The tumor had an unusual aggressive clinical behavior. Immunohistochemistry performed on the cell block let to establish the renal origin and the chromophobe histotype of malignant cells found in the pleural fluid.
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PMID:Malignant effusion of chromophobe renal-cell carcinoma: cytological and immunohistochemical findings. 2218 Feb 39