Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.11 (
CD10
)
9,792
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Maternal-fetal alloimmunisation with antenatal glomerulopathies (FMAIG) is a recently described allo-
immune disorder
that results from the production of maternal antibodies which cross the placenta, bind to fetal glomerular podocytes and thereby cause renal dysfunction. The pathogenic antibodies are directed against
CD10
/
neutral endopeptidase
(
NEP
). The infant's mother is apparently healthy but is genetically
NEP
-deficient, and thus becomes immunized against
CD10
/
NEP
expressed by placental cells during her first pregnancy. This disease, that we have now diagnosed in five families, is the first described organ-specific disorder due to maternal-fetal allo-immunisation. Because future pregnancies in
CD10
/
NEP
-immunized mothers are at high risk for the fetus, antigen-driven therapies aimed at eliminating pathogenic antibodies are urgently needed. This will require identification of the pathogenic epitopes born by the antigen.
...
PMID:[Anti-CD 10 maternal-fetal allo-immunisation]. 2431 16
