Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.5 (
cathepsin D
)
4,130
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
cathepsin D
4126
cathepsin B
377
Mol
292
Sep
275
acid phosphatase
236
cathepsin
172
renin
169
beta-glucuronidase
149
hemoglobin
145
estrogen receptor
116
cathepsin L
113
endoplasmic reticulum
107
p53
105
caspase-3
102
LC3
101
SDS
95
pS2
93
aspartyl protease
92
collagen
90
amyloid precursor protein
85
insulin
82
p62
81
cathepsin E
81
glycoprotein
78
mannose 6-phosphate receptor
76
progesterone receptor
76
LAMP-1
74
membrane protein
73
ubiquitin
64
fibronectin
63
polypeptide
61
erbB-2
58
serum albumin
56
chymotrypsin
55
ATP
54
Ang II
53
ATPase
53
peptidase
50
proteasome
49
Rab7
48
BACE1
46
albumin
46
calpain
46
urokinase-type plasminogen activator
45
casein
44
cysteine protease
43
transferrin
43
protease inhibitor
43
Cathepsin B
41
collagenase
40
peroxidase
40
membrane-bound
40
PDB
40
lysozyme
38
cytochrome c
38
alkaline phosphatase
38
microsomal
37
epidermal growth factor receptor
37
superoxide dismutase
35
PLA
35
angiotensinogen
35
catalase
34
cathepsin G
34
cathepsin H
33
proliferating cell nuclear antigen
33
nodal
33
myelin basic protein
32
cytokine
32
angiotensin II
31
microtubule-associated protein
30
Ki-67
30
LAMP-2
30
oestrogen receptor
30
Bcl-2
30
fused
29
N-acetyl-beta-D-glucosaminidase
29
gut
29
mannose-6-phosphate receptor
28
cathepsin C
28
cathepsin B1
27
more...
Disease
cancer
432
breast cancer
385
tumor
364
Alzheimer's disease
176
carcinoma
110
MCF
104
SDS
95
metastases
77
ischemia
52
hepatocellular carcinoma
51
tumor progression
44
Parkinson's disease
41
neuronal ceroid lipofuscinosis
39
tumor growth
37
diabetes
32
carcinogenesis
31
colorectal cancer
30
hypertension
29
HIV
27
adenocarcinoma
26
dementia
26
prostate cancer
25
ovarian cancer
24
uterus
23
malaria
23
neuroblastoma
22
melanoma
21
arthritis
21
atherosclerosis
20
Mycobacterium
20
tuberculosis
20
plaque
19
aggressiveness
18
osteoarthritis
18
leukemia
17
rheumatoid arthritis
17
tumorigenesis
17
colon cancer
16
myocardial ischemia
16
celiac disease
16
endometrial cancer
16
ICD
16
primary tumor
15
lung cancer
15
gastric cancer
14
GSH
14
lymphoma
14
Schistosoma mansoni
14
AIDS
14
squamous cell carcinoma
13
epididymis
13
type 2 diabetes
13
multiple sclerosis
13
wasting
12
myocardial infarction
12
Schistosoma japonicum
12
cerebral ischemia
12
stroke
11
amyloidosis
11
CLN3
11
glioblastoma
11
myopathy
11
glioma
11
blindness
11
depression
10
hepatitis
10
epithelial ovarian cancer
10
malnutrition
10
muscular atrophy
10
SAR
9
amyotrophic lateral sclerosis
9
Niemann-Pick
9
non-small cell lung cancer
9
obesity
9
cold
9
heart failure
9
cirrhosis
9
Huntington's disease
8
adenoma
8
lysosomal storage disease
8
more...
Symptom
starvation
37
acidity
12
seizures
11
collapse
8
cachexia
5
HSA
4
hyperoxia
4
joint stiffness
3
functional recovery
3
anorexia
3
spasticity
3
pain
3
Decreased activity
2
Spots
2
acute stress
2
exhaustion
2
fatigue
2
hypoproteinemia
2
weakness
2
nausea
2
anesthesia
2
tremor
1
autodigestion
1
erythema
1
disturbed balance
1
low back pain
1
regurgitation
1
Anoxia
1
overweight
1
abnormal gait
1
diarrhea
1
despair
1
spasm
1
splenomegaly
1
syncope
1
microbial colonization
1
dyspnea
1
skin damage
1
vomiting
1
dry skin
1
arthralgia
1
analgesia
1
hypertonia
1
hypothermia
1
thinning
1
angina
1
chronic constipation
1
constipation
1
Drug
Dermatol
34
lysine
30
Pepstatin
28
ICI
28
Asn
24
Gel
21
Cardiovasc
15
ROS
14
uPA
13
NADH
12
CSF
11
RFP
10
CA-074
9
vitamin E
9
IFN-gamma
7
Albumin
6
Angiotensin II
6
MAP
5
Fraction
5
Leaf
5
CaCl2
4
NAG
4
Estrogens
4
Ammonium chloride
4
balanced salt solution
4
CaCl2
4
EE2
4
CaCl2
4
Monensin
4
ascorbate
4
IL-2
4
Retinoic acid
3
Growth hormone
3
caffeine
3
Growth hormone
3
Fulvestrant
3
PFT
3
PTH
3
Adriamycin
3
Silica
3
TiO2
2
Glutathione
2
MRC
2
Urokinase
2
CTX
2
citric acid
2
ZnCl2
2
PFA
2
L-tyrosine
2
HCH
2
lactose
2
Glucagon
2
Indomethacin
2
Propofol
2
Prednisolone
2
Vitamin E
2
Papain
2
Histamine
2
Isorenin
2
Ethanol
2
Herceptin
2
BCG vaccine
2
Thyroglobulin
2
Vitamin A
2
EPA
2
Parkin
2
SiO2
2
Parkin
2
TTC
2
ZnO
2
Gelatin
2
ZnCl2
2
DDAVP
1
DHT
1
Casodex
1
ISP
1
Taxol
1
BLM
1
Metrizamide
1
Ranibizumab
1
more...
Enzyme
cathepsin D
4130
cathepsin B
377
acid phosphatase
241
pepsin
170
renin
169
beta-glucuronidase
143
trypsin
136
cathepsin L
113
SMP
86
hexosaminidase
78
caspase-3
75
CD10
61
peroxidase
60
chymotrypsin
59
proteasome
58
urokinase-type plasminogen activator
57
ATPase
55
beta-galactosidase
53
plasmin
52
cathepsin G
47
collagenase
45
elastase
44
catalase
43
superoxide dismutase
42
ERK
42
sulfatase
42
papain
41
lysozyme
39
mitogen-activated protein kinase
39
alkaline phosphatase
38
lactate dehydrogenase
35
cathepsin C
34
cathepsin H
33
ACE
30
protein kinase
26
RNase
26
kallikrein
24
thrombin
23
alpha-mannosidase
23
alpha-glucosidase
22
gastricsin
22
endoglycosidase H
22
plasmepsin II
22
beta-glucosidase
21
beta-secretase
21
creatine kinase
21
carboxypeptidase Y
21
lipase
20
beta-glucosidase
19
glucocerebrosidase
19
DNase
19
DNase II
18
glutathione S-transferase
18
arylsulfatase
18
tissue plasminogen activator
18
chymosin
17
RNase
17
PRA
16
protein kinase C
16
phosphatidylinositol 3-kinase
16
matrix metalloproteinase 2
16
caspase-8
15
caspase-9
15
leucine aminopeptidase
15
luciferase
15
HIV-1 protease
15
calcineurin
14
neutrophil elastase
13
alpha-L-fucosidase
13
AMP-activated protein kinase
13
ATP synthase
13
arylsulfatase A
13
m-calpain
12
PARP
12
glutathione peroxidase
12
reverse transcriptase
11
proteinase A
11
proteinase A
11
dipeptidyl peptidase IV
10
chymase
10
more...
Compound
Dec
264
DNA
209
cysteine
182
phosphate
147
galactose
128
Clin
128
Phe
125
sodium
121
leucine
117
oxygen
101
serine
99
SDS
98
alanine
97
arginine
86
sulfate
83
calcium
79
lysine
79
Asp
75
methionine
65
water
64
Pepstatin
60
nitrogen
57
tyrosine
56
glucose
55
ATP
54
Gly
51
ammonium
48
MDA
47
NH2
46
Ile
45
His
43
urea
40
GlcNAc
37
glucose-6-phosphate
36
hydrogen
34
EDTA
32
acetate
32
Triton X-100
32
EDTA
32
DEAE
32
zinc
31
aspartic acid
31
aspartic acid
30
salt
30
aspartic acid
30
aspartic acid
30
Statin
28
ICI
28
acridine
26
iron
25
threonine
24
TOF
22
ethanol
22
UDP-GlcNAc
21
Estrogen
21
Insulin
20
E-64
20
TCA
20
Estrogen
19
TNF
19
nitric oxide
17
copper
17
acetone
17
THP
17
THP
17
GSH
16
Chloroquine
16
AMP
16
prostacyclin
16
Chloroquine
16
GSH
16
Neuronal
15
silver
15
cAMP
15
formaldehyde
15
proline
15
Leupeptin
14
PMSF
14
Leupeptin
14
acetic acid
13
more...