Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.5 (cathepsin D)
4,130 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cathepsin D 4126
cathepsin B 377
Mol 292
Sep 275
acid phosphatase 236
cathepsin 172
renin 169
beta-glucuronidase 149
hemoglobin 145
estrogen receptor 116
cathepsin L 113
endoplasmic reticulum 107
p53 105
caspase-3 102
LC3 101
SDS 95
pS2 93
aspartyl protease 92
collagen 90
amyloid precursor protein 85
insulin 82
p62 81
cathepsin E 81
glycoprotein 78
mannose 6-phosphate receptor 76
progesterone receptor 76
LAMP-1 74
membrane protein 73
ubiquitin 64
fibronectin 63
polypeptide 61
erbB-2 58
serum albumin 56
chymotrypsin 55
ATP 54
Ang II 53
ATPase 53
peptidase 50
proteasome 49
Rab7 48
BACE1 46
albumin 46
calpain 46
urokinase-type plasminogen activator 45
casein 44
cysteine protease 43
transferrin 43
protease inhibitor 43
Cathepsin B 41
collagenase 40
peroxidase 40
membrane-bound 40
PDB 40
lysozyme 38
cytochrome c 38
alkaline phosphatase 38
microsomal 37
epidermal growth factor receptor 37
superoxide dismutase 35
PLA 35
angiotensinogen 35
catalase 34
cathepsin G 34
cathepsin H 33
proliferating cell nuclear antigen 33
nodal 33
myelin basic protein 32
cytokine 32
angiotensin II 31
microtubule-associated protein 30
Ki-67 30
LAMP-2 30
oestrogen receptor 30
Bcl-2 30
fused 29
N-acetyl-beta-D-glucosaminidase 29
gut 29
mannose-6-phosphate receptor 28
cathepsin C 28
cathepsin B1 27
more...
Disease
cancer 432
breast cancer 385
tumor 364
Alzheimer's disease 176
carcinoma 110
MCF 104
SDS 95
metastases 77
ischemia 52
hepatocellular carcinoma 51
tumor progression 44
Parkinson's disease 41
neuronal ceroid lipofuscinosis 39
tumor growth 37
diabetes 32
carcinogenesis 31
colorectal cancer 30
hypertension 29
HIV 27
adenocarcinoma 26
dementia 26
prostate cancer 25
ovarian cancer 24
uterus 23
malaria 23
neuroblastoma 22
melanoma 21
arthritis 21
atherosclerosis 20
Mycobacterium 20
tuberculosis 20
plaque 19
aggressiveness 18
osteoarthritis 18
leukemia 17
rheumatoid arthritis 17
tumorigenesis 17
colon cancer 16
myocardial ischemia 16
celiac disease 16
endometrial cancer 16
ICD 16
primary tumor 15
lung cancer 15
gastric cancer 14
GSH 14
lymphoma 14
Schistosoma mansoni 14
AIDS 14
squamous cell carcinoma 13
epididymis 13
type 2 diabetes 13
multiple sclerosis 13
wasting 12
myocardial infarction 12
Schistosoma japonicum 12
cerebral ischemia 12
stroke 11
amyloidosis 11
CLN3 11
glioblastoma 11
myopathy 11
glioma 11
blindness 11
depression 10
hepatitis 10
epithelial ovarian cancer 10
malnutrition 10
muscular atrophy 10
SAR 9
amyotrophic lateral sclerosis 9
Niemann-Pick 9
non-small cell lung cancer 9
obesity 9
cold 9
heart failure 9
cirrhosis 9
Huntington's disease 8
adenoma 8
lysosomal storage disease 8
more...
Symptom
starvation 37
acidity 12
seizures 11
collapse 8
cachexia 5
HSA 4
hyperoxia 4
joint stiffness 3
functional recovery 3
anorexia 3
spasticity 3
pain 3
Decreased activity 2
Spots 2
acute stress 2
exhaustion 2
fatigue 2
hypoproteinemia 2
weakness 2
nausea 2
anesthesia 2
tremor 1
autodigestion 1
erythema 1
disturbed balance 1
low back pain 1
regurgitation 1
Anoxia 1
overweight 1
abnormal gait 1
diarrhea 1
despair 1
spasm 1
splenomegaly 1
syncope 1
microbial colonization 1
dyspnea 1
skin damage 1
vomiting 1
dry skin 1
arthralgia 1
analgesia 1
hypertonia 1
hypothermia 1
thinning 1
angina 1
chronic constipation 1
constipation 1
Drug
Dermatol 34
lysine 30
Pepstatin 28
ICI 28
Asn 24
Gel 21
Cardiovasc 15
ROS 14
uPA 13
NADH 12
CSF 11
RFP 10
CA-074 9
vitamin E 9
IFN-gamma 7
Albumin 6
Angiotensin II 6
MAP 5
Fraction 5
Leaf 5
CaCl2 4
NAG 4
Estrogens 4
Ammonium chloride 4
balanced salt solution 4
CaCl2 4
EE2 4
CaCl2 4
Monensin 4
ascorbate 4
IL-2 4
Retinoic acid 3
Growth hormone 3
caffeine 3
Growth hormone 3
Fulvestrant 3
PFT 3
PTH 3
Adriamycin 3
Silica 3
TiO2 2
Glutathione 2
MRC 2
Urokinase 2
CTX 2
citric acid 2
ZnCl2 2
PFA 2
L-tyrosine 2
HCH 2
lactose 2
Glucagon 2
Indomethacin 2
Propofol 2
Prednisolone 2
Vitamin E 2
Papain 2
Histamine 2
Isorenin 2
Ethanol 2
Herceptin 2
BCG vaccine 2
Thyroglobulin 2
Vitamin A 2
EPA 2
Parkin 2
SiO2 2
Parkin 2
TTC 2
ZnO 2
Gelatin 2
ZnCl2 2
DDAVP 1
DHT 1
Casodex 1
ISP 1
Taxol 1
BLM 1
Metrizamide 1
Ranibizumab 1
more...
Enzyme
cathepsin D 4130
cathepsin B 377
acid phosphatase 241
pepsin 170
renin 169
beta-glucuronidase 143
trypsin 136
cathepsin L 113
SMP 86
hexosaminidase 78
caspase-3 75
CD10 61
peroxidase 60
chymotrypsin 59
proteasome 58
urokinase-type plasminogen activator 57
ATPase 55
beta-galactosidase 53
plasmin 52
cathepsin G 47
collagenase 45
elastase 44
catalase 43
superoxide dismutase 42
ERK 42
sulfatase 42
papain 41
lysozyme 39
mitogen-activated protein kinase 39
alkaline phosphatase 38
lactate dehydrogenase 35
cathepsin C 34
cathepsin H 33
ACE 30
protein kinase 26
RNase 26
kallikrein 24
thrombin 23
alpha-mannosidase 23
alpha-glucosidase 22
gastricsin 22
endoglycosidase H 22
plasmepsin II 22
beta-glucosidase 21
beta-secretase 21
creatine kinase 21
carboxypeptidase Y 21
lipase 20
beta-glucosidase 19
glucocerebrosidase 19
DNase 19
DNase II 18
glutathione S-transferase 18
arylsulfatase 18
tissue plasminogen activator 18
chymosin 17
RNase 17
PRA 16
protein kinase C 16
phosphatidylinositol 3-kinase 16
matrix metalloproteinase 2 16
caspase-8 15
caspase-9 15
leucine aminopeptidase 15
luciferase 15
HIV-1 protease 15
calcineurin 14
neutrophil elastase 13
alpha-L-fucosidase 13
AMP-activated protein kinase 13
ATP synthase 13
arylsulfatase A 13
m-calpain 12
PARP 12
glutathione peroxidase 12
reverse transcriptase 11
proteinase A 11
proteinase A 11
dipeptidyl peptidase IV 10
chymase 10
more...
Compound
Dec 264
DNA 209
cysteine 182
phosphate 147
galactose 128
Clin 128
Phe 125
sodium 121
leucine 117
oxygen 101
serine 99
SDS 98
alanine 97
arginine 86
sulfate 83
calcium 79
lysine 79
Asp 75
methionine 65
water 64
Pepstatin 60
nitrogen 57
tyrosine 56
glucose 55
ATP 54
Gly 51
ammonium 48
MDA 47
NH2 46
Ile 45
His 43
urea 40
GlcNAc 37
glucose-6-phosphate 36
hydrogen 34
EDTA 32
acetate 32
Triton X-100 32
EDTA 32
DEAE 32
zinc 31
aspartic acid 31
aspartic acid 30
salt 30
aspartic acid 30
aspartic acid 30
Statin 28
ICI 28
acridine 26
iron 25
threonine 24
TOF 22
ethanol 22
UDP-GlcNAc 21
Estrogen 21
Insulin 20
E-64 20
TCA 20
Estrogen 19
TNF 19
nitric oxide 17
copper 17
acetone 17
THP 17
THP 17
GSH 16
Chloroquine 16
AMP 16
prostacyclin 16
Chloroquine 16
GSH 16
Neuronal 15
silver 15
cAMP 15
formaldehyde 15
proline 15
Leupeptin 14
PMSF 14
Leupeptin 14
acetic acid 13
more...