Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.5 (cathepsin D)
 4,130 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
TBC1 domain family member 14 12.9
peroxisomal biogenesis factor 3 12.9
ADAM 32 12.9
cathepsin D 12.8
C14orf133 11.9
cadherin EGF LAG seven-pass G-type receptor 1 11.9
Rab40A 11.9
ubiquitin specific peptidase 10 11.9
isochorismatase domain containing 1 11.9
GNPTAG 11.6
PTAR1 11.3
SNC73 11.3
ATP6V0A1 11.3
RAB2A, member RAS oncogene family 11.3
lysosome-associated protein transmembrane 4 beta 11.3
PDA2 11.3
cathepsin E 11.1
CARP-2 10.9
RABGGTB 10.9
CD84-H1 10.9
PL48 10.9
RAB9B 10.9
cathepsin B1 10.8
DAP-1 10.7
gastricsin 10.6
MP78 10.6
ubiquinol-cytochrome c reductase binding protein 10.6
KIF5A protein 10.6
NESG1 10.6
ADAM30 10.6
gamma-synergin 10.6
engrailed homeobox 1 10.6
CVAK104 10.6
TGOLN2 10.6
transcription factor binding to IGHM enhancer 3 10.6
Syt V 10.6
tryptophan-tRNA ligase 10.6
TBC1D14 10.3
CLN6 protein 10.3
ubiquitin carrier protein E2 10.3
RBQ3 10.3
mutant CLN3 10.1
TUBA1 10.1
IGL@ 10.1
gamma2-adaptin 10.1
SEZ6L2 10.1
ZnT-6 10.1
ATP13A2 protein 10.1
mucolipin 3 10.1
FBXO27 10.1
CT120 10.1
actin related protein 2/3 complex 10.1
Cathepsin H 10.0
NDUFB5 9.9
TEF-5 9.9
TMEM55B 9.9
Aftiphilin 9.9
ATP6V0D1 9.9
BAG-2 9.9
DAP-3 9.9
MOX2 9.9
APR-1 9.8
EBAG9 9.8
APBB1 9.8
CTSB 9.8
aspartyl protease 9.8
ZnT-7 9.7
NCL protein 9.7
TP53RK 9.7
SNAPIN 9.7
ALCAT1 9.7
RAB26 9.7
lipophilin B 9.7
M6PR 9.6
plasma glutamate carboxypeptidase 9.6
Transmembrane protein 192 9.6
DAP-5 9.6
MCOLN3 9.6
nclf 9.6
HIP2 9.6
vacuolar protein sorting 35 9.5
synaptotagmin 5 9.5
TIMM23 9.5
Acid carboxypeptidase 9.5
phosphoserine aminotransferase 1 9.5
pMesogenin1 9.5
SH3GL3 9.5
RRAGA 9.5
PIP4K2C 9.5
NF-X1 9.5
RENIN 9.5
SDF4 9.5
cathepsin B 9.4
LAMP-2 9.4
mannose-6-phosphate receptor 9.4
cathepsin F 9.4
Beta-secretase 9.4
cathepsin H 9.3
ATP6V1H 9.3
cathepsin O 9.3
ZNHIT3 9.3
WIPI4 9.3
CLN7 9.3
RSP4 9.3
CTSL 9.3
cathepsin Z 9.3
ATP6V1E1 9.3
cathepsin L2 9.2
Phosphomonoesterase 9.2
nrs 9.2
huntingtin-interacting protein 1 9.2
UV radiation resistance associated gene 9.2
PSMB2 9.2
PRX2 9.2
actin beta 9.2
cathepsin C 9.2
pS2 9.2
CTSH 9.2
VPS41 9.2
ArPIKfyve 9.2
CYCLIN D3 9.1
MYO1E 9.1
ATAD3B 9.1
Ral guanine nucleotide exchange factor 9.1
ZNT5 9.1
EIF2S1 9.1
insulin-like growth factor 2 receptor 9.1
cathepsin A 9.1
mannose 6-phosphate receptor 9.1
damage-regulated autophagy modulator 9.1
LAMP-1 9.1
cathepsin 9.1
MPR 46 9.0
mannose 6-phosphate/insulin-like growth factor-II receptor 9.0
RAB2 9.0
HLA-DP beta 9.0
Golgi-associated ATPase enhancer of 16 kDa 9.0
prosaposin 9.0
PCPE 8.9
G-protein coupled receptor 56 8.9
SNCAIP 8.9
ACC-4 8.9
lamp-2 8.9
WSB1 8.9
elongation factor 1-beta 8.9
myosin-IC 8.9
ring finger protein 213 8.9
Cathepsin B 8.9
PRKAA 8.9
VPS33A 8.8
ATP1A4 8.8
transcription factor EC 8.8
GNPTG 8.8
ATP6V0D2 8.8
ZKSCAN3 8.8
LGP85 8.8
cathepsin L 8.8
APAA 8.8
muCANP 8.7
transcription factor EB 8.7
more...
Disease
placental cancer 10.9
WBC diseases 10.9
CLN10 10.9
Postpartum cardiomyopathy 10.6
CLN7 9.8
CLN9 9.7
SAPD 9.7
Morgagnian cataract 9.6
stage IIB cervical cancer 9.5
ML III 9.2
EBSS 8.9
CLN8 8.8
Granular corneal dystrophy 8.7
CLN5 8.6
Macular corneal dystrophy 8.5
CLN6 8.4
Bayle 8.2
neuronal ceroid lipofuscinosis 8.1
Mucolipidosis 8.1
SCCD 8.0
stage IB cervical cancer 8.0
benign proliferative breast disease 7.9
DIOS 7.8
Tubular carcinoma 7.8
familial hyperlipoproteinemia 7.8
EPPS 7.7
KRS 7.7
grade I meningioma 7.4
Recurrent seizures 7.3
CLN1 7.2
Kufs' disease 7.2
Unicameral bone cyst 6.9
CLN3 6.7
CLN2 6.7
IRMA 6.7
HCHWA 6.6
GFD 6.5
Intestinal infection 6.5
iris melanoma 6.4
Peripartum cardiomyopathy 6.4
hypertensive cardiomyopathy 6.3
fibrocystic breast disease 6.2
HOPS 6.2
SPG11 6.2
Salivary duct carcinoma 6.0
Danon disease 6.0
mixed gliomas 5.9
Pemphigus foliaceus 5.9
Medullary carcinoma 5.9
generalized tuberculosis 5.8
mouse leukemia L1210 5.7
infiltrating ductal carcinoma 5.6
stage II breast cancer 5.6
erythroplakia 5.6
malignant state 5.5
Hurler 5.5
fibrocystic disease 5.5
HS3 5.5
apocrine metaplasia 5.5
multicentric Castleman's disease 5.5
Alpers 5.4
Lowe syndrome 5.4
Schistosoma japonicum 5.4
lysosomal storage disease 5.4
DMC 5.3
Malassez 5.3
TRPS1 5.3
myoblastoma 5.3
FTLD 5.3
Goldblatt hypertension 5.3
Arthus reaction 5.2
terminal disease 5.2
Goldblatt 5.1
Desmoplastic 5.1
Niemann-Pick 5.1
MSF 5.1
supraglottis 5.0
Retinal degeneration 5.0
Netherton syndrome 5.0
Enzyme inhibition 4.9
NPC 4.9
Cat scratch disease 4.9
PARK7 4.9
APOA1 4.8
MCF 4.8
Sanfilippo 4.8
seborrheic keratosis 4.8
BPP 4.7
leukodystrophy 4.6
uvea 4.6
FFM 4.6
Mediterranean spotted fever 4.6
Candida albicans infection 4.6
GALT 4.6
MPS I 4.5
MPS VII 4.5
IBR 4.5
Breast carcinoma 4.5
HIV encephalitis 4.5
DMT1 4.5
Sanfilippo syndrome 4.5
glutaric aciduria 4.5
protein deficiency 4.5
FBS 4.4
HSP 4.4
Liver regeneration 4.4
PGS 4.4
Bielschowsky 4.4
Gaucher disease 4.4
harlequin 4.4
CHN 4.3
bubonic plague 4.3
cardiosclerosis 4.3
Hereditary spastic paraplegia 4.3
duodenitis 4.3
Plasmodium vivax malaria 4.3
PEM 4.2
Lowe 4.2
laryngeal squamous cell carcinoma 4.2
Lymph node metastases 4.2
Dementia with Lewy bodies 4.2
breast cancer 4.2
Vesicular stomatitis 4.2
Multiple system atrophy 4.2
endometrial adenocarcinoma 4.2
ASM 4.2
BCG infection 4.2
NPH 4.2
Mastitis 4.2
ST3 4.2
CSE 4.1
MEN 2B 4.1
idiopathic cardiomyopathy 4.1
carcinoma of the breast 4.1
Parry 4.1
CP1 4.1
clonorchiasis 4.1
Atrophic 4.0
benign nevi 4.0
Frontotemporal dementia 4.0
HRS 4.0
ichthyosis 4.0
Sandhoff disease 4.0
neonatal asphyxia 4.0
xerophthalmia 3.9
BLM 3.9
metastatic pancreatic cancer 3.9
Schistosoma mansoni 3.9
prostatic adenocarcinoma 3.9
metastatic colon cancer 3.9
keratosis 3.9
EDA 3.9
PCD 3.9
hookworm 3.9
signet ring cell carcinoma 3.9
SDS 3.9
TEC 3.8
ductal carcinoma in situ 3.8
lymphosarcoma 3.8
ichthyosis 3.8
more...
Symptom
Spots 5.1
disturbed balance 5.1
Decreased activity 4.9
autodigestion 4.6
joint stiffness 4.5
Anoxia 3.8
hypoproteinemia 3.8
starvation 3.5
HSA 3.4
dry skin 2.9
microbial colonization 2.9
abnormal gait 2.8
cachexia 2.8
hypertonia 2.6
acidity 2.6
chronic constipation 2.6
hyperoxia 2.6
skin damage 2.3
despair 2.3
spasticity 1.8
acute stress 1.7
collapse 1.1
functional recovery 0.8
anorexia 0.7
exhaustion 0.2
arthralgia 0.1
seizures 0.1
spasm 0.1
regurgitation -0.1
syncope -0.3
splenomegaly -0.4
low back pain -0.4
constipation -0.4
thinning -0.5
nausea -0.6
erythema -0.8
hypothermia -1.2
tremor -1.3
weakness -1.3
angina -1.5
fatigue -1.7
overweight -1.8
dyspnea -1.9
analgesia -1.9
vomiting -2.0
anesthesia -2.8
diarrhea -2.9
pain -3.5
Drug
Isorenin 11.6
Pepstatin 10.8
Methylprednisolone succinate 10.3
Pro-Banthine 9.5
Bv2 9.5
CA-074 9.3
Cimaterol 7.5
Ammonium chloride 7.0
Cortrosyn 7.0
Brij 96 6.9
Cortrosyn 6.7
Ceredase 6.7
Cerezyme 6.2
Gemifloxacin 6.1
Fulvestrant 6.0
RFP 6.0
Pertuzumab 5.9
uPA 5.6
PFT 5.6
3-Methyladenine 5.5
Casodex 5.3
ICI 5.3
Ranibizumab 5.2
Talc 5.2
Monensin 5.0
Thyroglobulin 5.0
CER 4.8
Papain 4.8
Bestatin 4.7
Senna 4.6
Urokinase 4.6
Senna 4.6
Meconium 4.6
Tao 4.3
SMP 4.3
balanced salt solution 4.3
Cilostazol 4.2
Hyaluronidase 4.1
Moxifloxacin 4.1
ISP 4.0
Asn 4.0
Hyaluronidase 4.0
PFA 3.9
Fraction 3.9
Iloprost 3.9
NAG 3.8
Estrogens 3.8
BCG vaccine 3.8
Metrizamide 3.7
ZnCl2 3.6
ZnCl2 3.6
Phosphatidylserine 3.5
Tocopherol 3.5
Gel 3.4
Camp 3.4
Prednisolone 3.4
Bupivacaine 3.3
Silica 3.3
Albumin 3.3
Norplant 3.2
Angiotensin II 3.2
Gelatin 3.2
Aprotinin 3.1
Photofrin 3.1
DFP 3.1
Parkin 3.0
TTC 3.0
Parkin 3.0
DDAVP 3.0
DDAVP 3.0
Growth hormone 3.0
Growth hormone 2.9
Propofol 2.9
Retinoic acid 2.8
Herceptin 2.8
AMC 2.7
L-tyrosine 2.7
Vitamin B 2.6
Methylene blue 2.6
CTC 2.6
NBT 2.5
BLM 2.5
IL-1ra 2.5
ROS 2.5
FeCl3 2.5
Vitamin A 2.3
Adriamycin 2.3
VCR 2.3
CaCl2 2.3
CaCl2 2.3
Triclosan 2.3
CaCl2 2.2
Vitamin E 2.2
MRC 2.2
Diurnal 2.2
HCH 2.2
Norplant 2.1
Bevacizumab 2.1
NaI 2.1
NaI 2.1
NaI 2.1
NaI 2.1
NADH 2.1
Glucagon 2.0
EE2 2.0
vitamin E 2.0
lysine 2.0
ADR 1.9
Frontal 1.9
EPI 1.9
ACT 1.8
DHT 1.8
G418 1.8
PTH 1.8
Captopril 1.8
DHT 1.7
Fragment 1.7
CDP 1.7
Forskolin 1.6
Glutathione 1.5
Fluorescein 1.5
Histamine 1.5
CSF 1.5
Rituximab 1.4
SiO2 1.4
IFN-beta 1.4
MAP 1.3
ADM 1.3
Indomethacin 1.3
Taxol 1.3
EPA 1.1
Fluorescein 1.0
IFN-gamma 0.9
Portal 0.9
Leaf 0.8
Ethanol 0.7
citric acid 0.6
CTX 0.6
TiO2 0.4
ascorbate 0.4
CAM 0.4
ZnO 0.2
caffeine 0.1
IL-2 0.1
Dermatol -0.0
ROC -0.0
DNase I -0.1
lactose -0.1
Biopolymers -0.1
ABC -0.2
Cardiovasc -0.8
Monit -2.2
Enzyme
cathepsin D 12.9
plasmepsin I 11.0
plasmepsin II 10.9
gastricsin 10.8
nepenthesin 10.7
phosphoglucokinase 10.6
cathepsin T 10.6
Candida albicans aspartic proteinase 10.6
N-acetylglucosaminylphosphotransferase 10.5
alpha-N-acetylglucosaminyl phosphodiesterase 10.4
SMP 9.9
carboxyl proteinase 9.9
cathepsin F 9.7
cathepsin B 9.4
cathepsin H 9.4
cathepsin C 9.4
cathepsin O 9.3
phytepsin 9.3
stratum corneum chymotryptic enzyme 9.2
beta-glycerophosphatase 9.2
rhizopuspepsin 9.0
yapsin 1 9.0
NS protease 8.9
proteinase A 8.9
cathepsin L 8.8
DAP II 8.7
cathepsin V 8.5
aminopeptidase Y 8.5
endothiapepsin 8.4
deuterolysin 8.4
DNase II 8.3
proteinase A 8.3
cathepsin X 8.3
chymosin 8.1
tripeptidyl peptidase 8.1
EC 2.4.99.1 8.1
methylmalonate-semialdehyde dehydrogenase 8.0
ficin 7.8
glutathione-insulin transhydrogenase 7.8
KLK7 7.7
carboxypeptidase S 7.7
MT 1 7.7
cathepsin G 7.7
aspartyl aminopeptidase 7.6
alpha-N-acetylglucosaminidase 7.6
penicillopepsin 7.6
galactosylhydroxylysyl glucosyltransferase 7.5
beta-secretase 7.5
memapsin 2 7.5
legumain 7.5
Rab geranylgeranyltransferase 7.5
hexosaminidase 7.4
m-AAA protease 7.4
arylsulfatase A 7.3
cathepsin S 7.3
thimet oligopeptidase 7.2
pepsin 7.2
acid phosphatase 7.2
beta-glucuronidase 7.2
aminopeptidase B 7.2
pyroglutamate aminopeptidase 7.1
alpha-L-fucosidase 7.1
UDP-N-acetylglucosamine pyrophosphorylase 7.1
CPA2 7.1
aminopeptidase I 7.0
carboxypeptidase Y 7.0
alpha-mannosidase 6.9
stromelysin-3 6.9
palmitoyl-protein thioesterase 6.9
arylsulfatase 6.8
m-calpain 6.8
glucosamine-6-phosphate deaminase 6.8
sulfatase 6.7
glucocerebrosidase 6.6
choline dehydrogenase 6.6
bleomycin hydrolase 6.6
endoglycosidase H 6.5
alpha-L-fucosidase 6.5
alpha-L-fucosidase 6.5
matrix metalloproteinase 14 6.5
EC 2.6.1.16 6.4
cancer procoagulant 6.4
phosphatidylinositol phospholipase C 6.3
PRA 6.2
p-nitrophenylphosphatase 6.2
glutaminyl cyclase 6.2
leucine aminopeptidase 6.1
aspartylglucosaminidase 6.1
ceramidase 6.1
prolyl endopeptidase 6.1
proteinase-3 6.1
peptidylarginine deiminase 6.0
EC 2.7.7.9 6.0
amidophosphoribosyltransferase 6.0
sulfhydryl oxidase 6.0
insulin-degrading enzyme 6.0
hydroxynitrile lyase 5.9
hydroxynitrile lyase 5.9
chymase 5.8
N-acetylgalactosaminidase 5.8
guanidinoacetate methyltransferase 5.8
HIV-1 protease 5.8
GalT 5.8
chymopapain 5.7
macrophage elastase 5.7
matrix metalloproteinase 2 5.7
bromelain 5.7
alanine aminopeptidase 5.7
beta-glucosidase 5.7
hydroxynitrile lyase 5.7
arabinosidase 5.7
endoproteinase Asp-N 5.7
lactic acid dehydrogenase 5.7
dimethylarginine dimethylaminohydrolase 5.7
calpain 3 5.6
chondroitinase AC 5.6
beta-glucosidase 5.6
tissue kallikrein 5.6
lactic acid dehydrogenase 5.6
neuropsin 5.6
protein disulfide-isomerase 5.6
papain 5.6
CD10 5.6
dipeptidyl peptidase IV 5.5
acrosin 5.5
plasmin 5.5
clotting enzyme 5.5
NAO 5.4
NADH-cytochrome b5 reductase 5.4
carboxypeptidase G2 5.4
glucosidase II 5.4
chymotrypsin 5.4
alpha-L-iduronidase 5.4
urokinase-type plasminogen activator 5.4
triose-phosphate isomerase 5.4
isopeptidase 5.4
lactic acid dehydrogenase 5.3
alpha-glucosidase 5.3
mannosidase II 5.3
PFI 5.3
carboxypeptidase A 5.3
beta-xylosidase 5.3
carboxypeptidase B 5.2
cathepsin K 5.2
elastase 5.2
mannosidase I 5.2
renin 5.2
TSP-1 5.2
alpha-galactosidase 5.2
histidase 5.0
eEF2 kinase 5.0
cholesterol esterase 5.0
caspase-6 5.0
PRPP synthetase 5.0
deoxyribonuclease 5.0
lysyl endopeptidase 5.0
lysyl hydroxylase 5.0
prolidase 5.0
caspase-6 4.9
kallikrein 4.9
more...
Compound
6-cyclohexylhexanoic acid 11.9
6-cyclohexylhexanoic acid 11.9
C18H16O8 11.3
Gardenin B 10.9
Pepstatin 10.9
Gardenin 10.1
Pinane 10.0
A 435 9.7
Methyl caffeate 9.7
Cyprodinil 9.3
5-phenylpentanoic acid 9.2
Hydroxytamoxifen 9.1
CMP-N-acetylneuraminate 9.0
Xanthomicrol 9.0
CMP-N-acetylneuraminate 9.0
3-methylbenzaldehyde 8.9
Benzophenone-1 8.7
1H-indole-3-carbaldehyde 8.6
Trimethyltin chloride 8.6
1H-indole-3-carbaldehyde 8.6
1H-indole-3-carbaldehyde 8.6
1H-indole-3-carbaldehyde 8.6
1H-indole-3-carbaldehyde 8.6
Fast Garnet GBC 8.6
Leupeptin 8.6
1H-indole-3-carbaldehyde 8.4
1H-indole-3-carbaldehyde 8.3
Leupeptin 8.3
Citreoviridin 8.2
EPNP 8.2
Ginkgetin 8.2
Aziridine 8.1
1H-indole-3-carbaldehyde 8.1
2-ethoxy-2-oxoethyl 8.1
Streptolydigin 8.0
Anisodamine 7.9
1H-indole-3-carbaldehyde 7.9
1H-indole-3-carbaldehyde 7.8
Bisphenol AF 7.7
hydroxyethylamine 7.7
PAMBA 7.6
Statin 7.4
Tiapamil 7.4
E-64 7.4
Brucine 7.3
KNI-272 7.3
N-Hydroxysuccinimide 7.3
Mr 30 7.2
DPBS 7.2
Anacardic acid 7.1
Lynestrenol 7.1
N-acetyltryptophan 7.0
N-acetyltryptophan 7.0
Procion Yellow 7.0
His-Leu 6.9
Zinc pyrithione 6.8
CLTC 6.8
Zinc pyrithione 6.8
Zinc pyrithione 6.8
Angiotensin I 6.8
Pentobarbital 6.7
Medroxyprogesterone 6.6
Acridine Orange 6.5
Acridine Orange 6.5
Acridine Orange 6.5
UDP-GlcNAc 6.5
beta-tocopherol 6.5
Fast Blue B 6.4
TPCK 6.4
Pipecolic acid 6.3
glucose-6-phosphate 6.3
PMSF 6.2
Tanakan 6.2
TCTP 6.2
2-OHE1 6.2
4-chlorobenzoic acid 6.2
norleucine 6.2
NIX 6.1
DFD 6.1
methyl butyrate 6.1
4-chlorobenzoic acid 6.1
Chloroquine 6.1
Chloroquine 6.0
Guanabenz 6.0
4-chlorobenzoic acid 6.0
Triphosphate 6.0
Triton WR-1339 5.9
BAPN 5.9
Pentobarbital 5.9
Plasmin 5.9
norleucine 5.8
piperidine-2-carboxylic acid 5.8
Tocopherols 5.8
Iodoacetamide 5.8
Coomassie Brilliant Blue G 5.8
TFF 5.7
6-Gingerol 5.7
benzenesulfonyl fluoride 5.7
Pyocyanin 5.7
2-cyclohexen-1-one 5.7
Paraformaldehyde 5.6
Chondroitin 5.6
3-Methyladenine 5.5
Brefeldin A 5.5
Brefeldin A 5.5
4-OHT 5.5
7beta-hydroxycholesterol 5.5
Cysteamine 5.4
AF-2 5.4
DTE 5.4
Nonylphenol 5.3
ICRF-187 5.2
IAN 5.2
Paraformaldehyde 5.2
VLA 5.2
Fucoidan 5.1
DCI 5.1
TIF 5.1
ICI 5.1
4-chlorobenzyl 5.1
Monensin 5.1
MNA 5.0
MNA 5.0
(-)-Epigallocatechin 5.0
2-furoic acid 4.9
3-methylhistidine 4.9
DFS 4.9
Formin 4.8
Quinacrine 4.8
acridine 4.8
Glu-Glu 4.8
6-aminohexanoic acid 4.8
Miconazole 4.8
6-aminohexanoic acid 4.8
Ethambutol 4.8
PCMB 4.8
PCMB 4.8
PCMB 4.8
Suramin 4.7
PCMB 4.7
Milrinone 4.7
Honokiol 4.6
DMC 4.6
PCB 126 4.6
Bestatin 4.5
TDT 4.5
ORO 4.5
Collagenase 4.5
Nocodazole 4.5
6-Hydroxydopamine 4.5
Puromycin 4.5
aspartic acid 4.5
L-leucine 4.5
aspartic acid 4.5
1,3-D 4.4
Trypan Blue 4.4
Xanthine 4.4
GlcNAc 4.4
2,5-hexanedione 4.4
VPM 4.4
more...