Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.5 (
cathepsin D
)
4,130
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Native LDL are degraded by the protease of the lysosomal extract but they are not sensitive to isolated
cathepsin D
.
Protamine
increases the sensitivity of LDL to the effect of lysosomal protease and makes them sensitive to the effect of
cathepsin D
. Degradation of LDL by lysosomal protease is most intensive between pH 4.0 and 4.5 but in case of LDL bound with protamine it is most intensive at pH 4.5--5.0.
...
PMID:Degradation of low-density lipoproteins (LDL) and LDL - protamine complexes by lysosomal protease. 3 17
