Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.5 (
cathepsin D
)
4,130
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have detected, solubilized, and purified to near-homogeneity a membrane-bound acid protease from rabbit reticulocytes. Chemical, physical, immunological, and catalytic characterization demonstrate that the enzyme is
cathepsin D
. With cytochrome b5 as substrate, the enzyme shows a surprisingly high pH optimum and is stimulated by ATP and
DPG
. Possible roles for the protease include protein processing of microsomal enzymes, degradation of subcellular organelles, and destruction of excess hemoglobin chains. The possible role of
cathepsin D
in protein processing of microsomal enzymes will be best assessed by the molecular biological approaches described in the following two presentations.
...
PMID:Cathepsin D in erythroid cells. 269 41
