Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.5 (
cathepsin D
)
4,130
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The degradation of 32P-labelled E. coli and the activity of three lysosomal enzymes, acid phosphatase,
cathepsin D
and beta-glucuronidase, in mouse peritoneal macrophages (MPM) were tested after cultivation of the cells for 24 or 48 hours with 10(1) - 10(4.7) U per ml of a homologous beta-interferon preparation (
IFN-beta
). Low to moderate concentrations of
IFN-beta
did not influence bacterial degradation in MPM. However, a reduction in bacterial degradation by 20 per cent or more was seen when the MPM were pre-treated with 10(4.7) U per ml for 24 hours or 10(3) U per ml of
IFN-beta
for 48 hours. Cultivation of the MPM with 10(2) U per ml of
IFN-beta
suppressed the activities of the lysosomal enzymes, provided that the cells were treated for 48 hours. The beta--glucuronidase activity was significantly reduced also after 24 hours. Increased release of beta-glucuronidase from MPM to the medium during cultivation with 10(2) U per ml of
IFN-beta
was also observed. Specific anti-
IFN-beta
globulin abolished the suppression by
IFN-beta
on the lysosomal enzyme activities. A human IFN-alpha preparation did not influence bacterial degradation or lysosomal enzyme activities in MPM.
...
PMID:Effect of a homologous beta-interferon preparation on degradation of Escherichia coli and on lysosomal enzyme activities in mouse peritoneal macrophages. 617 90
