Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.5 (cathepsin D)
 4,130 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Samples of subretinal fluid (SRF) from patients with primary rhegmatogeneous retinal detachment of various duration were studied using standard enzymologic techniques. The protein content in SRF increased with the duration of detachment. The activities of lysosomal enzymes in SRF, which were acid phosphatase, beta-glucuronidase, and cathepsin D, also increased with the duration of detachment. Especially cathepsin D, which was not detected in serum, was present in SRF. The activity of a nonlysosomal enzyme, i. e., lactic dehydrogenase, which was used as a marker of cell disruption and of serum transudation was the same as that of serum. Because lysosomal enzymes are known to be able to degrade cells and tissues, the enzymologic analysis of SRF contributes to our understanding of the pathology of primary rhegmatogeneous retinal detachment.
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PMID:Lysosomal enzymes in subretinal fluid. 108 77

Lysosomal enzymes are distributed widely in various ocular tissues. Among these tissues, the uvea and retina show the higher enzyme activities of acid phosphates, beta-blucuronidase, alpha-fucosidase, alpha-mannosidase, arylsulfatase, cathepsin D, cathepsin B and others. The particular role of lysosomal enzymes in the pathogenic processes of ocular diseases such as storage disease, uveitis, retinal degeneration, retinal detachment, corneal dystrophy and glaucoma is strongly suggested. The enzymes also have additional importance in ocular physiopathology.
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PMID:Lysosomal enzymes in ocular tissues and diseases. 634 90

It was found that subretinal fluid contains at least two different proteolytic enzymes which digest various protein substrates. The main of them was identified as cathepsin D. This protease is very active towards the denatured haemoglobin. The highest activity is apparent at pH 3-4 and it is completely inhibited by the action of pepstatin. The cathepsin activity increases with the duration of retinal detachment. The other proteolytic enzyme acts at slightly alkaline pH. Its activity is lower and does not change with the duration of the disease.
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PMID:Cathepsin D and an alkaline protease activities in subretinal fluid. 883 22